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. 2024 Oct 17:15:1475244.
doi: 10.3389/fphar.2024.1475244. eCollection 2024.

Analysis of the evolution of placental oxidative stress research from a bibliometric perspective

Ailing Chen  1 , Mengyuan Tian  1 , Zouqing Luo  1 , Xiaohui Cao  1 , Yanfang Gu  1
Affiliations

Analysis of the evolution of placental oxidative stress research from a bibliometric perspective

Ailing Chen et al. Front Pharmacol. .

Abstract

Background: Research on placental oxidative stress is pivotal for comprehending pregnancy-related physiological changes and disease mechanisms. Despite recent advancements, a comprehensive review of current status, hotspots, and trends remains challenging. This bibliometric study systematically analyzes the evolution of placental oxidative stress research, offering a reference for future studies.

Objective: To conduct a comprehensive bibliometric analysis of the literature on placental oxidative stress to identify research hotspots, trends, and key contributors, thereby providing guidance for future research.

Methods: Relevant data were retrieved from the Web of Science Core Collection database and analyzed using VOSviewer, CiteSpace, and the bibliometrix package. An in-depth analysis of 4,796 publications was conducted, focusing on publication year, country/region, institution, author, journal, references, and keywords. Data collection concluded on 29 April 2024.

Results: A total of 4,796 papers were retrieved from 1,173 journals, authored by 18,835 researchers from 4,257 institutions across 103 countries/regions. From 1991 to 2023, annual publications on placental oxidative stress increased from 7 to 359. The United States (1,222 publications, 64,158 citations), the University of Cambridge (125 publications, 13,562 citations), and Graham J. Burton (73 publications, 11,182 citations) were the most productive country, institution, and author, respectively. The journal Placenta had the highest number of publications (329) and citations (17,152), followed by the International Journal of Molecular Sciences (122 publications). The most frequent keywords were "oxidative stress," "expression," "pregnancy," "preeclampsia," and "lipid peroxidation." Emerging high-frequency keywords included "gestational diabetes mellitus," "health," "autophagy," "pathophysiology," "infection," "preterm birth," "stem cell," and "inflammation."

Conclusion: Over the past 3 decades, research has concentrated on oxidative stress processes, antioxidant mechanisms, pregnancy-related diseases, and gene expression regulation. Current research frontiers involve exploring pathophysiology and mechanisms, assessing emerging risk factors and environmental impacts, advancing cell biology and stem cell research, and understanding the complex interactions of inflammation and immune regulation. These studies elucidate the mechanisms of placental oxidative stress, offering essential scientific evidence for future intervention strategies, therapeutic approaches, and public health policies.

Keywords: VOSviewer; bibliometrics; citespace; emerging topics; oxidative stress; placenta; research focus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow-chart of the search process.
FIGURE 2
FIGURE 2
A bibliometric analysis of research on placental oxidative stress. (A) Bibliometric Data Overview. (B) Distribution of “Placental Oxidative Stress” publications over time.
FIGURE 3
FIGURE 3
Collaboration network of countries/regions/institutions. (A) Distribution and collaboration of publications among countries/regions. (B) CiteSpace: visualizing clusters of cooperation among countries/regions. (C) VOSviewer: visualizing clusters of cooperation among countries/regions. (D) Visualization map of institutional collaboration.
FIGURE 4
FIGURE 4
Collaboration network of authors. (A) Authors’ production over time. (B) Visualization map of author collaboration. (C) Co-citation analysis of cited authors.
FIGURE 5
FIGURE 5
Analysis of journal sources. (A) Co-citation analysis of cited sources. (B) Dual-Map overlay of journals publishing research on Placental Oxidative Stress.
FIGURE 6
FIGURE 6
Highly cited and co-cited references. (A) Top 10 most cited articles in Placental oxidative stress. (B) Cluster analysis of co-cited references.
FIGURE 7
FIGURE 7
Analysis of keywords associated with Placental Oxidative Stress. (A) Word cloud analysis. (B) Clustering of keywords.
FIGURE 8
FIGURE 8
Keyword analysis in Placental Oxidative Stress. (A) Burst detection of keywords. (B) Trend topics analysis. (C) A timeline visualization in CiteSpace.
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