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Case Reports
. 2024 Oct 2;29(19):102599.
doi: 10.1016/j.jaccas.2024.102599.

Minoxidil-Related Pericarditis

Farah Abdulhai  1 , Gary Parizher  2 , Mohamad Zmaili  2 , Ushasi Saraswati  1 , Zoha Majeed  1 , Muhammad Majid  2 , Alveena Batool Syed  2 , Seth Scheetz  2 , Anthony Fernandez  3 , Allan L Klein  2
Affiliations
Case Reports

Minoxidil-Related Pericarditis

Farah Abdulhai et al. JACC Case Rep. .

Abstract

This paper reports a case of a 53-year-old man presenting with recurrent pericardial effusions and one episode of pericarditis after short-term, low-dose minoxidil use, without prior kidney or heart failure history. The uniqueness lies in the rapid onset of a moderate pericardial effusion within 20 days, notably shorter than previously documented.

Keywords: cardiac magnetic resonance; echocardiography; pericardial effusion.

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Conflict of interest statement

Dr Klein has received research funding from Kiniksa Pharmaceuticals, Ltd and Cardiol Therapeutics; and has served on scientific advisory boards for Kiniksa Pharmaceuticals, Ltd, Swedish Orphan Biovitrum AB, Cardiol Therapeutics, and Pfizer, Inc. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Timeline of Events (A) TTE showing a moderate circumferential pericardial effusion (arrow). (B) TTE showing a large circumferential pericardial effusion with the peak pericardial effusion adjacent to posterior left ventricle measuring 3.86 cm (arrow). (C) Follow-up TTE 3 months after stopping minoxidil with resolution of pericardial effusion. (D) Follow-up CMR at the midventricle (papillary muscles) PSIR with trivial LGE. LGE shown by yellow arrows. (E) Follow-up CMR T2 STIR at the midventricle (papillary muscles) with no pericardial edema or thickening. CCF = Cleveland Clinic Foundation; CMR = cardiac magnetic resonance; LGE = late gadolinium enhancement; PSIR = phase-sensitive inversion recovery; STIR = short inversion time inversion recovery; TTE = transthoracic echocardiogram.
See this image and copyright information in PMC

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