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Randomized Controlled Trial
. 2024 Nov 1;316(10):732.
doi: 10.1007/s00403-024-03430-1.

Efficacy and safety of topical spironolactone versus topical dapsone in the treatment of acne vulgaris

Khaled Gharib  1 , Mai Samir  2 , Gehad Mohamed  2 , Mahmoud A Rageh  3
Affiliations
Randomized Controlled Trial

Efficacy and safety of topical spironolactone versus topical dapsone in the treatment of acne vulgaris

Khaled Gharib et al. Arch Dermatol Res. .

Abstract

Acne vulgaris is a common skin disease that greatly impacts the quality of life of affected individuals. Several treatment modalities are available for acne, with variable degrees of success. Our aim was to compare the safety and efficacy of topical spironolactone 5% gel and topical dapsone 5% gel as treatment modalities for acne vulgaris. The study included 28 patients with mild to moderate acne. They were randomly divided into two equal groups. Group I treated with topical spironolactone 5% gel, and group II treated with topical dapsone 5% gel. In both groups, the gel was applied twice daily for 12 weeks, and patients were evaluated using the acne severity index. Group I included 14 patients [11 (78.6%) females and 3 (21.4%) males]. More than one-half of this group (64.3%) had moderate acne severity. Group II included 14 patients [12 (85.7%) females and 2 (14.3%) males]. Half of patients had moderate acne severity. Therapeutic response was poor, moderate, good, and excellent (14.3%), (28.6%), (50%), (7.1%), respectively, in topical spironolactone group versus poor, moderate, and good (50%), (42.9%), (7.1%), respectively, in topical dapsone group. The therapeutic response between the studied groups was statistically significant in favor of the topical spironolactone group. Regarding adverse effects, burning sensation was evident after application of topical spironolactone while itching was significantly common with topical dapsone. The data provided by the current study support the use of topical spironolactone 5% gel in treating acne vulgaris in both male and female patients.

Keywords: Acne; Acne vulgaris; Dapsone; Spironolactone.

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