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. 2025 Feb;211(2):266-268.
doi: 10.1164/rccm.202407-1353RL.

Vitamin D Supplementation, Long-Term PM2.5 Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Post Hoc Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA)

Franziska J Rosser  1 , Yueh-Ying Han  1 , Erick Forno  2 , Theresa W Guilbert  3 , Leonard B Bacharier  4 , Wanda Phipatanakul  5 , Juan C Celedón  1
Affiliations

Vitamin D Supplementation, Long-Term PM2.5 Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Post Hoc Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA)

Franziska J Rosser et al. Am J Respir Crit Care Med. 2025 Feb.
No abstract available

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References

    1. Rosser F, Brehm JM, Forno E, Acosta-Perez E, Kurland K, Canino G, et al. Proximity to a major road, vitamin D insufficiency, and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med . 2014;190:1190–1193. - PMC - PubMed
    1. Bose S, Breysse PN, McCormack MC, Hansel NN, Rusher RR, Matsui E, et al. Center for Childhood Asthma in the Urban Environment Outdoor exposure and vitamin D levels in urban children with asthma. Nutr J . 2013;12:81. - PMC - PubMed
    1. Knihtila HM, Huang M, Prince N, Stubbs BJ, Carey VJ, Laranjo N, et al. Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function. J Allergy Clin Immunol . 2023;151:556–564. - PMC - PubMed
    1. Forno E, Bacharier LB, Phipatanakul W, Guilbert TW, Cabana MD, Ross K, et al. Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels: the VDKA randomized clinical trial. JAMA . 2020;324:752–760. - PMC - PubMed
    1. Rosser FJ, Han YY, Forno E, Guilbert TW, Bacharier LB, Phipatanakul W, et al. Long-term exposure to particulate matter <2.5 µm and lung function change in children with asthma receiving inhaled corticosteroids. Am J Respir Crit Care Med . 2023;208:622–624. - PubMed

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