Prevention, Diagnosis, and Treatment of Tuberculosis in Children with Human Immunodeficiency Virus

Abstract

While tuberculosis (TB) is an ancient disease, its global prevalence and concomitant human immunodeficiency virus (HIV)-1 infection have hampered efforts at effectively controlling TB in children in many countries where these 2 pandemics coexist. This review briefly discusses the current status of TB prevention strategies including preventative regimens designed to prevent the progression of latent TB infection to active disease, current recommendations regarding treatment of TB disease, and the problematic nature of diagnosing TB in children living with HIV. Promising recent data regarding novel diagnostic techniques that rely upon detecting Mycobacterium tuberculosis molecular components in blood will be reviewed.

Keywords: Diagnosis; Pediatrics; Prevention and treatment; Tuberculosis.