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. 2024 Nov 2;28(1):147.
doi: 10.1007/s10151-024-03020-3.

Oncologic outcomes and trends in each colon cancer location and stages over the last two decades: insights from the SEER registry

C Benlice  1 , A H Elhan  2 , M E Seker  3 , E Gorgun  4 , M A Kuzu  5
Affiliations

Oncologic outcomes and trends in each colon cancer location and stages over the last two decades: insights from the SEER registry

C Benlice et al. Tech Coloproctol. .

Abstract

Background: The main purpose of the study is to comprehensively evaluate population-level survival disparities stage-by-stage, according to specific anatomical colon segments, and based on prognosis as defined by lymph nodes among patients who have undergone curative resection for non-metastatic colon cancer.

Methods: The study was conducted from the Surveillance Epidemiology and End Result (SEER) program from the USA. Patients who underwent surgery for colon adenocarcinoma between 2000 and 2019 were identified. Demographics and clinical and pathologic factors were compared amongst each other according to different colon segments, stages, and time periods.

Results: A total of 482,672 patients were identified and 195,105 of them met the inclusion criteria. Patients with proximal cancers were significantly older, more likely to be female, had a higher number of lymph nodes, and node positivity (p < 0.001). During the study period, an almost 10% improvement in overall survival rate was observed at 3 and 5 years for each colon site and stage (p < 0.05).

Conclusions: The study's findings revealed a notable improvement in overall and cancer-specific survival rates across all colon segments and stages in patients who underwent curative treatment for non-metastatic primary colon cancer from a nationwide database.

Keywords: Colon cancer; Overall and site-oriented survival; SEER data.

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References

    1. Yamauchi M, Morikawa T, Kuchiba A et al (2012) Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61(6):847–854 - DOI - PubMed
    1. Azzoni C, Bottarelli L, Campanini N et al (2007) Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. Int J Colorectal Dis 22:115–126 - DOI - PubMed
    1. Bhangu A, Kiran RP, Slesser A et al (2013) Survival after resection of colorectal cancer based on anatomical segment of involvement. Ann Surg Oncol 20:4161–4168 - DOI - PubMed
    1. Brenne SS, Ness-Jensen E, Edna T, Lydersen S, Laugsand EA (2023) Risk factors for right colon, left colon and rectal cancers differ between men and women: the population-based HUNT study in Norway. Colorectal Dis 25(1):44–55 - DOI - PubMed
    1. Weiss JM, Pfau PR, O’Connor ES et al (2011) Mortality by stage for right-versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results–medicare data. J Clin Oncol 29(33):4401 - DOI - PubMed - PMC

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