Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Feb;30(1-2):401-421.
doi: 10.1007/s10495-024-02038-0. Epub 2024 Nov 2.

Advancements in programmed cell death research in antitumor therapy: a comprehensive overview

Shuxin Wei  1   2 , Chuangye Han  3   2 , Shutian Mo  3 , Hailian Huang  1   2 , Xiaoling Luo  4   5   6
Affiliations
Review

Advancements in programmed cell death research in antitumor therapy: a comprehensive overview

Shuxin Wei et al. Apoptosis. 2025 Feb.

Abstract

Cell death is a normal physiological process within cells that involves multiple pathways, such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell death has been a hot spot of research in tumor-related fields, especially programmed cell death, which is a key form of cell death and is classified into different types according to the mechanism of occurrence, such as apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and disulfidptosis. Given the important role of PCD in maintaining tissue homeostasis and inhibiting tumorigenesis and development, more and more basic and clinical studies are devoted to revealing its potential application in anti-tumor strategies. The purpose of this review is to systematically review the regulatory mechanisms of PCD and to summarize the latest research progress of anti-tumor treatment strategies based on PCD.

Keywords: Cell death; Programmed cell death; Targeted therapy; Tumor.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

    1. Pan F. He Jie (2022) academician team released that lung cancer is the first cause of death of cancer in China[J]. Chinese contemporary medicine, 29(10):1–2
    1. Calabrese C,Davidson N Rdemircioglu D,(2020),genomic basisfor RNA alterations in cancer[J]. Nature,578(7793):129–136
    1. Galluzzi L et al (2018) Molecular mechanisms of cell death: recommendations of the nomenclature Committee on Cell Death 2018. Cell Death Differ 25:486–541 - DOI - PubMed - PMC
    1. Christgen S, Tweedell R, Kanneganti T (2022) Programming inflammatory cell death for therapy. Pharmacol Therapeut 232:108010 - DOI
    1. KERR JF, WYLLIE AH, CURRIE AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics[J]. Br J Cancer 26(4):239–257. https://doi.org/10.1038/bjc.1972.33 - DOI - PubMed - PMC

Publication types

Substances

LinkOut - more resources