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Review
. 2024 Nov 2;6(1):19.
doi: 10.1186/s42522-024-00115-7.

Combating antibiotic resistance in a one health context: a plethora of frontiers

Daniel Jesuwenu Ajose  1   2 , Abimbola Olumide Adekanmbi  3 , Nor Fadhilah Kamaruzzaman  4 , Collins Njie Ateba  5   6 , Shamsaldeen Ibrahim Saeed  7   8   9
Affiliations
Review

Combating antibiotic resistance in a one health context: a plethora of frontiers

Daniel Jesuwenu Ajose et al. One Health Outlook. .

Abstract

One of the most significant medical advancements of the 20th century was the discovery of antibiotics, which continue to play a vital tool in the treatment and prevention of diseases in humans and animals. However, the imprudent use of antibiotics in all fields of One-Health and concerns about antibiotic resistance among bacterial pathogens have raised interest in antibiotic use restrictions on a global scale. Despite the failure of conventional antimicrobial agents, only about 15 new antibiotics have been introduced clinically since year 2000 to date. Moreover, there has been reports of resistance to some of these new antibiotics. This has necessitated a need to search for alternative strategies to combat antimicrobial resistant pathogens. Thus, this review compiles and evaluates the approaches-natural compounds, phage treatment, and nanomaterials-that are being used and/or suggested as the potential substitutes for conventional antibiotics.

Keywords: Alternative therapy; Antimicrobial resistance; Natural product/compound; One-health; Secondary metabolite.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results”.

Figures

Fig. 1
Fig. 1
Transmission routes of AMR bacteria between human, animal and the environment Adapted from: [10]
Fig. 2
Fig. 2
Variables that contribute to antibiotic resistance
Fig. 3
Fig. 3
Timeline showing the discovery of antibiotics and the rise of antibiotic resistance over the course of eight decades. XDR – Extensive-drug resistant, PDR – Pan-drug resistant
Fig. 4
Fig. 4
Mechanisms of antimicrobial resistance in bacteria cells
Fig. 5
Fig. 5
Antimicrobial peptides mechanisms of action
See this image and copyright information in PMC

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