MB declares grant funding from Wellcome Trust, Medical Research Future Fund, Victorian Government Department of Jobs, Precincts and Regions, Janssen Lundbeckfonden Copenhagen, St Biopharma, Milken Baszucki Brain Research Fund, Stanley Medical Research Institute, Danmarks Frie Forskningsfond Psykiatrisk Center Kovenhavn, Patient-Centered Outcomes Research Institute, US Department of Defense Office of the Congressionally Directed Medical Research Programs, and Equity Trustees. MB declares participation on advisory boards for Janssen, Otsuka, St Biopharma, Actinogen, and Servier, outside the submitted work. DJS reports personal fees from Discovery Vitality, Johnson & Johnson, Kanna, L'Oreal, Lundbeck, Orion, Sanofi, Servier, Takeda, and Vistagen. LJW declares no competing interests. MB is supported by a Leadership 3 Investigator grant (2017131) from the Australian National Health and Medical Research Council. LJW is supported by an Australian National Health and Medical Research Council Emerging Leadership grant (1174060). DJS is supported by the South African Medical Research Council.