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. 2024 Nov 3;23(1):335.
doi: 10.1186/s12944-024-02323-6.

Association between triglyceride-glucose index and fractional exhaled nitric oxide in adults with asthma from NHANES 2007-2012

Yao Pan #  1 , Lizhen Wu #  2 , Shiyi Yao #  3 , Jing Xia #  4 , Mohan Giri  3 , Jun Wen  5 , Sanmei Zhuang  6
Affiliations

Association between triglyceride-glucose index and fractional exhaled nitric oxide in adults with asthma from NHANES 2007-2012

Yao Pan et al. Lipids Health Dis. .

Abstract

Background: Several studies have shown a potential relationship between triglyceride-glucose index (TGI) and asthma. However, limited research has been conducted on the relationship between TGI and fractional exhaled nitric oxide (FeNO).

Methods: A total of 1,910 asthmatic individuals from the National Health and Nutrition Examination Survey (NHANES) database were included in this study. Linear regression analyses were used to investigate the relationship between TGI and FeNO in patients with asthma. Subsequently, a trend test was applied to verify whether there was a linear relationship between the TGI and FeNO. Finally, a subgroup analysis was performed to confirm the relationship among the different subgroup populations.

Results: Multivariable linear regression analyses showed that TGI was linearly related to FeNO in the asthmatic population. The trend test additionally validated the positive linear relationship between TGI and FeNO. The result of XGBoost revealed the five most influential factors on FeNO in a ranking of contrasted importance: eosinophil (EOS), body mass index (BMI), poverty-to-income ratio (PIR), TGI, and white blood cell count (WBC).

Conclusions: This investigation revealed a positive linear relationship between TGI and FeNO in patients with asthma. This finding suggests a potential relationship between TGI and airway inflammation in patients with asthma, thereby facilitating the prompt identification of irregularities and providing a basis for clinical decision making. This study provides a novel perspective on asthma management.

Keywords: Asthma; Fractional exhaled nitric oxide (FeNO); Triglyceride-glucose index (TGI); XGBoost.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart for choosing populations for study
Fig. 2
Fig. 2
The XGBoost model provided the relative importance of each variable on FeNO
See this image and copyright information in PMC

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