Global Health Priority Box─Proactive Pandemic Preparedness

Abstract

The coronavirus pandemic outbreak of 2019 highlighted the critical importance of preparedness for current and future public health threats (https://www.mmv.org/mmv-open/global-health-priority-box/about-global-health-priority-box). While the main attention for the past few years has been on COVID-19 research, this focus has reduced global resources on research in other areas, including malaria and neglected tropical diseases (NTDs). Such a shift in focus puts at risk the hard-earned progress in global health achieved over the past two decades (https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021). To address the urgent need for new drugs to combat drug-resistant malaria, emerging zoonotic diseases, and vector control, Medicines for Malaria Venture (MMV) and Innovative Vector Control Consortium (IVCC) assembled a collection of 240 compounds and, in August 2022, launched the Global Health Priority Box (GHPB). This collection of compounds has confirmed activity against emerging pathogens or vectors and is available free of charge. This valuable tool enables researchers worldwide to build on each other's work and save precious time and resources by providing a starting point for the further development of treatments and insecticides. Furthermore, this open access box aligns with two of the many priorities outlined by the World Health Organization (WHO) (https://www.who.int/news-room/spotlight/10-global-health-issues-to-track-in-2021).

Keywords: Resistant malaria; drug discovery; neglected diseases; open access box; vector control; zoonotic diseases.

Figure 1

Constituents of the Global Health Priority Box.

Figure 2

Vector plate selection workflow.

Figure 3

Classes of compounds included in the Vector Control Plate.

Figure 4

Zoonotic disease compound selection workflow

Figure 5

Classes of compound included in the Zoonotic disease plate.

Figure 6

Disease area segregation.

Figure 7

Malaria plate selection workflow.

Figure 8

Pathogen diversity in the requests.

Figure 9

Number of requests by disease area.