doi: 10.1016/0014-2999(86)90480-2.
Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum
- PMID: 3948925
- DOI: 10.1016/0014-2999(86)90480-2
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Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum
Eur J Pharmacol.
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Abstract
Capsaicin induces a transient relaxation of the isolated rat duodenum in the presence of atropine plus guanethidine. The relaxant effect of capsaicin was not observed in vitro in the duodenum of capsaicin-pretreated animals. Capsaicin-induced relaxation was antagonized by tetrodotoxin or cold storage (24 h at 4 degrees C). It is concluded that capsaicin produces a neurogenic relaxation of the rat duodenum by activating an intramural non-adrenergic non-cholinergic mechanism which inhibits intestinal motility.
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