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. 1986 Jan 29;120(3):367-70.
doi: 10.1016/0014-2999(86)90480-2.

Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum

C A Maggi, P Santicioli, S Manzini, A Meli

Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum

C A Maggi et al. Eur J Pharmacol. .

Abstract

Capsaicin induces a transient relaxation of the isolated rat duodenum in the presence of atropine plus guanethidine. The relaxant effect of capsaicin was not observed in vitro in the duodenum of capsaicin-pretreated animals. Capsaicin-induced relaxation was antagonized by tetrodotoxin or cold storage (24 h at 4 degrees C). It is concluded that capsaicin produces a neurogenic relaxation of the rat duodenum by activating an intramural non-adrenergic non-cholinergic mechanism which inhibits intestinal motility.

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