Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jan;55(1):67-74.
doi: 10.1111/cea.14590. Epub 2024 Nov 3.

MiR-107 and Its Association With House Dust Mite Sensitisation: Implications for Asthma

Byung-Keun Kim  1   2 , Min-Suk Yang  1   3 , Upasna Srivastava  1   4 , Shraddha Piparia  1 , Rinku Sharma  5 , Anshul Tiwari  6 , Alvin Kho  7 , Richard Wong  1   8 , Juan C Celedón  9 , Scott T Weiss  5 , Michael McGeachie  5 , Kelan Tantisira  1   8
Affiliations

MiR-107 and Its Association With House Dust Mite Sensitisation: Implications for Asthma

Byung-Keun Kim et al. Clin Exp Allergy. 2025 Jan.

Abstract

Introduction: MicroRNAs (miRNAs) have been linked to allergic diseases but their effects on sensitisation to allergens in individuals with asthma are unknown. We aimed to identify miRNAs associated with house dust mite (HDM) sensitisation in childhood asthma.

Methods: Serum samples from 1126 children with asthma who participated in the Genetics of Asthma in Costa Rica Study (GACRS) were profiled for 304 miRNAs. We first divided according to HDM sensitisation and then tested whether miRNAs were differentially expressed (DE) between the two groups. Gene enrichment analysis for target genes of the DE miRNAs was then performed to identify potential causal pathways. Replication analysis was performed in the Childhood Asthma Management Program (CAMP), in which expression data of 258 miRNAs in 491 children were available. A mediation analysis was conducted to discern relationships between miRNA and phenotype differences according to HDM sensitisation in GACRS cohort.

Results: There were 906 (80.5%) and 220 (19.5%) subjects in the GACRS HDM+ and HDM- groups. Compared with HDM- participants, those in the HDM+ group were more likely to be severe in variables including pulmonary function, oral corticosteroid use and blood tests. A total of 17 miRNAs were DE (p < 0.05) between the two groups, with miR-642a-3p, let-7c-5p and miR-107 most significantly associated with HDM sensitisation. In CAMP, there were 39 DE miRNAs, and increased expression of miR-107 in HDM+ children was replicated in this cohort. In both GACRS and CAMP, the cadherin-binding pathway was enriched in an analysis of target genes for DE miRNA. In a mediation analysis, miR-107 showed significant indirect effects on eosinophil count and total IgE that were mediated by HDM sensitisation.

Conclusion: In children with asthma, miR-107 is associated with HDM sensitisation. Furthermore, miR-107 was indirectly associated with total IgE and eosinophil count through HDM sensitisation.

Keywords: MiR‐107; asthma; house dust mite; microRNA.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

All other authors declare no conflicts of interest.

Similar articles

See all similar articles

Cited by

References

    1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2023. Available from: www.ginasthma.org.
    1. Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368(9537):763–70. - PubMed
    1. Gregory LG, Lloyd CM. Orchestrating house dust mite-associated allergy in the lung. Trends Immunol. 2011;32(9):402–11. - PMC - PubMed
    1. Kho AT, McGeachie MJ, Moore KG, Sylvia JM, Weiss ST, Tantisira KG. Circulating microRNAs and prediction of asthma exacerbation in childhood asthma. Respir Res. 2018;19(1):128. - PMC - PubMed
    1. Kho AT, Sharma S, Davis JS, Spina J, Howard D, McEnroy K, et al. Circulating MicroRNAs: Association with Lung Function in Asthma. PLoS One. 2016;11(6):e0157998. - PMC - PubMed