Sinonasal Papillomas-An Up-To-Date Review for Practicing Pathologists

Abstract

Sinonasal papillomas are a group of uncommon benign neoplasms that often represent a diagnostic challenge for surgical pathologists due to their diverse morphologic features. Our understanding of the molecular pathogenesis of these tumors has made significant advances recently that have reinforced the histology-based classification that was introduced over 50 years ago. As some subtypes have features that overlap with other sinonasal tumors, including specific carcinomas such as DEK::AFF2 nonkeratinizing squamous cell carcinoma, being aware of their key diagnostic findings is vital for appropriate classification.

Keywords: Epidermal growth factor receptor (EGFR); Exophytic sinonasal papilloma (ESP); Human papillomavirus (HPV); Inverted sinonasal papilloma (ISP); KRAS; Oncocytic sinonasal papilloma (OSP); Sinonasal squamous cell carcinoma.