273rd ENMC International workshop: Clinico-Sero-morphological classification of the Antisynthetase syndrome. Amsterdam, The Netherlands, 27-29 October 2023

Werner Stenzel¹, Andrew L Mammen², Laure Gallay³, Marie-Therese Holzer⁴, Felix Kleefeld⁵, Olivier Benveniste⁶, Yves Allenbach⁷; ENMC Antisynthetase Syndrome Study Group

Collaborators, Affiliations

Collaborators

ENMC Antisynthetase Syndrome Study Group:
Yves Allenbach⁷, Olivier Benveniste⁷, Jan Damoiseaux⁸, Sonye K Danoff⁹, Louise Diederichsen¹⁰, David Fiorentino¹¹, Laure Gallay³, Margherita Giannini¹², Marie-Therese Holzer⁴, Felix Kleefeld⁵, Lia Kolsters¹³, Ingrid Lundberg¹⁴, Andrew L Mammen¹⁵, Alain Meyer¹², Ioanna Minopulou¹⁶, Corinna Preusse¹⁷, Tobias Ruck¹⁸, Jantima Tanboon¹⁹, Sarah L Tansley²⁰, Werner Stenzel²¹, Yurdagul Uzunhan²²

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: werner.stenzel@charite.de.
² National Institutes of Health, Bethesda, Maryland, USA.
³ Institut Neuromyogène, PGNM, CNRS UMR5310 INSERM U1217, Clinical immunology department and reference center for auto-immune disease, Place d'Arsonvaal, Hopital Edouard Herriot, 69003 Lyon, France.
⁴ Division of Rheumatology and Systemic Inflammatory Diseases, III, Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
⁵ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of clinical and experimental Neurology, Charitéplatz 1, 10117 Berlin, Germany.
⁶ Sorbonne Université, Assistance Publique Hôpitaux de Paris, National Reference Center for Inflammatory Myopathies, Pitié-Salpêtrière Hospital, 85 Bd de l'Hôpital, 75013 Paris, France. Electronic address: olivier.benveniste@aphp.fr.
⁷ Sorbonne Université, Assistance Publique Hôpitaux de Paris, National Reference Center for Inflammatory Myopathies, Pitié-Salpêtrière Hospital, 85 Bd de l'Hôpital, 75013 Paris, France.
⁸ Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
⁹ Johns Hopkins Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 E. Monument Street, Baltimore, MD 21287 USA.
¹⁰ Dept. of Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark and Dept. of Rheumatology, Odense University Hospital, Odense, Denmark.
¹¹ Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, 94063 USA.
¹² Department of Physiology and Functional Explorations, Referral Centre for Systemic Rare Auto-immune Diseases (RESO), Biomedicine Research Centre of Strasbourg (CRBS), mitochondria, oxidative stress, and muscular plasticity laboratory (UR 3072), University hospital of Strasbourg, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France.
¹³ Patient Representative, The Netherlands.
¹⁴ Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet.
¹⁵ Dr Andrew Lee Mammen, National Institutes of Health, Bethesda, Maryland, USA.
¹⁶ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of clinical and experimental Rheumatology, Charitéplatz 1, 10117 Berlin, Germany.
¹⁷ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Neurology, Charitéplatz 1, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropaediatrics, Augustenburger Platz 1, 13353 Berlin, Germany.
¹⁸ Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
¹⁹ Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²⁰ Department of Life Sciences, University of Bath, Bath, UK & Royal National Hospital for Rheumatics Diseases, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
²¹ Charité - Universitätsmedizin Berlin,     corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany.
²² Department of Respiratory Medicine, Reference Centre for Rare Pulmonary Diseases, APHP, Hôpital Avicenne, INSERM U 1272, Université Sorbonne Paris-Nord, Bobigny, France.

PMID: 39490006
DOI: 10.1016/j.nmd.2024.104453

273rd ENMC International workshop: Clinico-Sero-morphological classification of the Antisynthetase syndrome. Amsterdam, The Netherlands, 27-29 October 2023

Werner Stenzel et al. Neuromuscul Disord. 2024 Dec.

. 2024 Dec:45:104453.

doi: 10.1016/j.nmd.2024.104453. Epub 2024 Oct 4.

Authors

Werner Stenzel¹, Andrew L Mammen², Laure Gallay³, Marie-Therese Holzer⁴, Felix Kleefeld⁵, Olivier Benveniste⁶, Yves Allenbach⁷; ENMC Antisynthetase Syndrome Study Group

Collaborators

ENMC Antisynthetase Syndrome Study Group:
Yves Allenbach⁷, Olivier Benveniste⁷, Jan Damoiseaux⁸, Sonye K Danoff⁹, Louise Diederichsen¹⁰, David Fiorentino¹¹, Laure Gallay³, Margherita Giannini¹², Marie-Therese Holzer⁴, Felix Kleefeld⁵, Lia Kolsters¹³, Ingrid Lundberg¹⁴, Andrew L Mammen¹⁵, Alain Meyer¹², Ioanna Minopulou¹⁶, Corinna Preusse¹⁷, Tobias Ruck¹⁸, Jantima Tanboon¹⁹, Sarah L Tansley²⁰, Werner Stenzel²¹, Yurdagul Uzunhan²²

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: werner.stenzel@charite.de.
² National Institutes of Health, Bethesda, Maryland, USA.
³ Institut Neuromyogène, PGNM, CNRS UMR5310 INSERM U1217, Clinical immunology department and reference center for auto-immune disease, Place d'Arsonvaal, Hopital Edouard Herriot, 69003 Lyon, France.
⁴ Division of Rheumatology and Systemic Inflammatory Diseases, III, Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
⁵ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of clinical and experimental Neurology, Charitéplatz 1, 10117 Berlin, Germany.
⁶ Sorbonne Université, Assistance Publique Hôpitaux de Paris, National Reference Center for Inflammatory Myopathies, Pitié-Salpêtrière Hospital, 85 Bd de l'Hôpital, 75013 Paris, France. Electronic address: olivier.benveniste@aphp.fr.
⁷ Sorbonne Université, Assistance Publique Hôpitaux de Paris, National Reference Center for Inflammatory Myopathies, Pitié-Salpêtrière Hospital, 85 Bd de l'Hôpital, 75013 Paris, France.
⁸ Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
⁹ Johns Hopkins Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, 1830 E. Monument Street, Baltimore, MD 21287 USA.
¹⁰ Dept. of Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark and Dept. of Rheumatology, Odense University Hospital, Odense, Denmark.
¹¹ Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, 94063 USA.
¹² Department of Physiology and Functional Explorations, Referral Centre for Systemic Rare Auto-immune Diseases (RESO), Biomedicine Research Centre of Strasbourg (CRBS), mitochondria, oxidative stress, and muscular plasticity laboratory (UR 3072), University hospital of Strasbourg, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France.
¹³ Patient Representative, The Netherlands.
¹⁴ Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet.
¹⁵ Dr Andrew Lee Mammen, National Institutes of Health, Bethesda, Maryland, USA.
¹⁶ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of clinical and experimental Rheumatology, Charitéplatz 1, 10117 Berlin, Germany.
¹⁷ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Neurology, Charitéplatz 1, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropaediatrics, Augustenburger Platz 1, 13353 Berlin, Germany.
¹⁸ Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
¹⁹ Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²⁰ Department of Life Sciences, University of Bath, Bath, UK & Royal National Hospital for Rheumatics Diseases, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
²¹ Charité - Universitätsmedizin Berlin,     corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany.
²² Department of Respiratory Medicine, Reference Centre for Rare Pulmonary Diseases, APHP, Hôpital Avicenne, INSERM U 1272, Université Sorbonne Paris-Nord, Bobigny, France.

PMID: 39490006
DOI: 10.1016/j.nmd.2024.104453

Abstract

Among the idiopathic inflammatory myopathies, patients harbouring an Antisynthetase syndrome exhibit a unique clinical picture, with characteristic signs such as myositis, interstitial lung disease, arthritis, rash, and/or fever. Characteristic morphological features on skeletal muscle biopsies differentiate Antisynthetase syndrome from other forms of myositis. Autoantibodies typically recognizing one of the members of the aminoacyl-tRNA synthetase family of proteins can be detected in the serum of such patients, with anti-Jo1 being most frequent. Until now, an international consensus definition of the Antisynthetase syndrome is lacking, hence this workshop has undertaken the task to inform about the clinical, morphological and autoantibody profiles of Antisynthetase syndrome. The authors also expand their aims by giving management and therapeutic strategies, and finally provide precise classification criteria for Antisynthetase syndrome.

Keywords: Anti-synthetase syndrome; Idiopathic inflammatory myopathies; tRNA synthetase autoantibodies, ILD, arthritis.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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273rd ENMC International workshop: Clinico-Sero-morphological classification of the Antisynthetase syndrome. Amsterdam, The Netherlands, 27-29 October 2023

Collaborators

Affiliations

273rd ENMC International workshop: Clinico-Sero-morphological classification of the Antisynthetase syndrome. Amsterdam, The Netherlands, 27-29 October 2023

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

Supplementary concepts