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. 2025 May-Jun;15(3):e286-e294.
doi: 10.1016/j.prro.2024.10.007. Epub 2024 Oct 28.

Management of de Novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) and the Role of Radiation Therapy: A Consensus by the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

Andrea Lancia  1 , Anna Rita Alitto  2 , Giovanni Pappagallo  3 , Elisa Ciurlia  4 , Giulio Francolini  5 , Rolando D'Angelillo  6 , Sergio Fersino  7 , Niccolò Giaj Levra  8 , Barbara Alicja Jereczek-Fossa  9 , Alessandro Magli  10 , Francesco Pasqualetti  11 , Alessia Reali  12 , Corrado Spatola  13 , Luca Triggiani  14
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Free article

Management of de Novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) and the Role of Radiation Therapy: A Consensus by the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

Andrea Lancia et al. Pract Radiat Oncol. 2025 May-Jun.
Free article

Abstract

Purpose: Prostate cancer treatments paradigms are in continuous evolution, especially in the metastatic setting. In this context, the Genito-Urinary Group of Italian Association of Radiotherapy and Clinical Oncology aimed to create a consensus on radiation therapy indication in de novo metastatic hormone-sensitive prostate cancer both on primary tumor and metastatic sites.

Methods: A panel of experts, involved in clinical management of prostate cancer, through the estimate-talk-estimate method, developed a list of items and correspondent statements on the identified topic.

Results: Seven conclusive items were identified with 12 statements about the chosen topic, radiation therapy in metastatic hormone-sensitive prostate cancer on primary tumor and metastatic sites.

Conclusions: This consensus might help clinicians in prostate cancer managing in daily clinical practice.

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Conflict of interest statement

Disclosures Barbara Alicja Jereczek-Fossa reported research funding from ACCURAY, IBA, AIRC (Italian Association for Cancer Research) and Fondazione IEO-CCM (Istituto Europeo di Oncologia-Centro Cardiologico Monzino). Niccolò Giaj Levra reported funds from AstraZeneca, Amgen, Janseen. Andrea Lancia, Anna Rita Alitto, Giovanni Pappagallo, Francesco Pasqualetti, Luca Triggiani, Elisa Ciurlia, Alessandro Magli, Sergio Fersino, Giulio Francolini, Alessia Reali, Rolando D'Angelillo, and Corrado Spatola had no funds to report.

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