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Review
. 2024 Dec:264:108747.
doi: 10.1016/j.pharmthera.2024.108747. Epub 2024 Nov 2.

Lipoprotection in cardiovascular diseases

Marcel Benkhoff  1 , Amin Polzin  2
Affiliations
Free article
Review

Lipoprotection in cardiovascular diseases

Marcel Benkhoff et al. Pharmacol Ther. 2024 Dec.
Free article

Abstract

Cardioprotection is a well-established term in the scientific world. It describes the protection of various mediators on the cardiovascular system. These protective effects can also be provided by certain lipids. Since lipids are a very specific and clearly definable class of substances, we define the term lipoprotection as lipid-mediated cardioprotection. In this review, we highlight high-density lipoprotein (HDL), sphingosine-1-phosphate (S1P) and omega-3 polyunsaturated fatty acids (n-3 PUFA) as the most important lipoprotective mediators and show their beneficial impact on coronary artery disease (CAD), acute myocardial infarction (AMI) and heart failure (HF).

Keywords: Acute myocardial infarction; Coronary artery disease; Heart failure; Lipoprotection; Sphingosine-1-phosphate.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Amin Polzin reports financial support was provided by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation). Marcel Benkhoff reports financial support was provided by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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