The protective effects of medicinal plants against cigarette smoking: A comprehensive review

Abstract

Backgrounds: Cigarette smoking remains a pervasive and harmful habit, and it poses a significant public health concern globally. Tobacco smoke contains numerous toxicants and carcinogens that contribute to the incidence of various diseases, including respiratory ailments, cancer, and cardiovascular disorders. Over the past decade, there has been a growing interest in exploring natural remedies to mitigate the harmful effects of cigarette smoke (CS). Medicinal plants, with their rich phytochemical compositions, have emerged as potential sources of protective agents against CS-induced damage.

Objectives: The current review attempts to comprehensively review and provide a thorough analysis of the protective effects of medicinal plants, including ginseng, Aloe vera, Olea europaea, Zea mays, green tea, etc. against CS-related toxicities.

Materials and methods: A comprehensive research and compilation of existing literature were conducted. We conducted a literature search using the Web of Science, PubMed, Scopus, and Google Scholar. We selected articles published in English between 1987 and 2025. The search was performed using keywords including cigarette smoking, cigarette smokers, second-hand smokers, natural compounds, plant extracts, naturally derived products, natural resources, phytochemicals, and medicinal plants.

Results: This review critically investigated recent literature focusing on the effects of medicinal plant extracts, essential oils, and isolated compounds on reducing the adverse consequences of CS exposure. These investigations encompassed several in vivo, in vitro, and clinical trials, clarifying the mechanisms underlying the protective effects of these plants. The notable antioxidant, anti-inflammatory, and detoxifying properties of these botanical interventions were also highlighted.

Conclusion: Collectively, this review emphasizes the potential of medicinal plants in alleviating the harmful effects of CS. The rich active constituents present in these plants offer various mechanisms that counteract oxidative stress, inflammation, and carcinogenesis induced by CS exposure. Further research is warranted to reveal the precise molecular mechanisms, derive dosing recommendations, and explore the efficacy of botanical interventions in large-scale clinical trials, ultimately improving public health outcomes and providing valuable insights for the smoking population worldwide.

Keywords: Cigarettes smoke; Hedgehog signaling pathway; Medicinal plants; Nrf2 pathway; Oxidative stress; Protective effects.