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. 1986 Jan;27(1):78-85.
doi: 10.1136/gut.27.1.78.

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

T J Mitchell, J M Ketley, S C Haslam, J Stephen, D W Burdon, D C Candy, R Daniel

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

T J Mitchell et al. Gut. 1986 Jan.

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

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