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. 2025;26(8):1232-1244.
doi: 10.2174/0113892010325685241029113633.

Establishing a Novel Pyroptosis-related Gene Signature and Predicting Chemical Drugs for Papillary Thyroid Cancer

Ru Wang  1 , Xin Chen  1 , Dandan Yi  1 , Chaoyu Jiang  1 , Fazhan Xu  2 , Jiabo Qin  2 , YiHsuan Lee  2 , Jianfeng Sang  1 , Xianbiao Shi  1
Affiliations

Establishing a Novel Pyroptosis-related Gene Signature and Predicting Chemical Drugs for Papillary Thyroid Cancer

Ru Wang et al. Curr Pharm Biotechnol. 2025.

Abstract

Background: The present study aimed to construct a novel pyroptosis-related gene signature to predict the prognosis of papillary thyroid cancer (PTC).

Methods: The gene expression level and survival and prognosis information of PTC were obtained from TCGA. The differentially expressed pyroptosis-related genes (DEPs) between cancer and control groups were selected, followed by subtype analysis. A prognostic model was built using LASSO regression analysis. The samples were then divided into high- and low-risk groups, and the differences in immune cell distribution in different risk groups were compared. The chemical drugs associated with genes in the prognostic model were extracted from the Comparative Toxicogenomics Database.

Results: A total of 31 DEPs were selected, and 3 different subtypes were obtained. A prognostic model based on 6 pyroptosis-related genes was constructed. The risk grouping was significantly correlated with the actual prognosis, and the model was found to be an independent prognostic factor. Six immune cells with significant differences in distribution in different risk groups were screened. CGP52608 could target four genes in the prognostic model, including GSDMB, NLRC4, IL1A, and IL6.

Conclusion: The present study constructed a pyroptosis-related gene signature that could predict the prognosis of PTC. Additionally, this signature was correlated with tumor immunity.

Keywords: Pyroptosis; gene; immune; papillary thyroid cancer; prognosis; signature..

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References

    1. Chen D.W.; Lang B.H.H.; McLeod D.S.A.; Newbold K.; Haymart M.R.; Thyroid cancer. Lancet 2023,401(10387),1531-1544 - DOI - PubMed
    1. National guidelines for diagnosis and treatment of thyroid cancer 2022 in China (English version). Chin J Cancer Res National Health Commission Of The People's Republic Of China 2022,34(3),131-150 - DOI - PubMed
    1. Ito Y.; Miyauchi A.; Kihara M.; Fukushima M.; Higashiyama T.; Miya A.; Overall survival of papillary thyroid carcinoma patients: A single-institution long-term follow-up of 5897 patients. World J Surg 2018,42(3),615-622 - DOI - PubMed
    1. Xie Z.; Li X.; He Y.; Wu S.; Wang S.; Sun J.; Lun Y.; Xin S.; Zhang J.; Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods. BMC Cancer 2020,20(1),1143 - DOI - PubMed
    1. Kim S.K.; Kwon A.Y.; Back K.; Park I.; Hur N.; Lee J.H.; Choe J.H.; Kim J.H.; Oh Y.L.; Kim J.S.; Predictive factors of lymph node metastasis in follicular variant of papillary thyroid carcinoma. Ann Surg Oncol 2017,24(9),2617-2623 - DOI - PubMed

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