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Review
. 2024 Aug 16;33(15):3387-3400.
doi: 10.1007/s10068-024-01678-x. eCollection 2024 Dec.

Molecular mechanism of skeletal muscle loss and its prevention by natural resources

Jin Tae Kim  1   2 , Dong Hyeon Jeon  1   2 , Hong Jin Lee  1   2
Affiliations
Review

Molecular mechanism of skeletal muscle loss and its prevention by natural resources

Jin Tae Kim et al. Food Sci Biotechnol. .

Abstract

A skeletal muscle disorder has drawn attention due to the global aging issues. The loss of skeletal muscle mass has been suggested to be from the reduced muscle regeneration by dysfunction of muscle satellite cell/fibro-adipogenic progenitor cells and the muscle atrophy by dysfunction of mitochondria, ubiquitin-proteasome system, and autophagy. In this review, we highlighted the underlying mechanisms of skeletal muscle mass loss including Notch signaling, Wnt/β-catenin signaling, Hedgehog signaling, AMP-activated protein kinase (AMPK) signaling, and mammalian target of rapamycin (mTOR) signaling. In addition, we summarized accumulated studies of natural resources investigating their roles in ameliorating the loss of skeletal muscle mass and demonstrating the underlying mechanisms in vitro and in vivo. In conclusion, following the studies of natural resources exerting the preventive activity in muscle mass loss, the signaling-based approaches may accelerate the development of functional foods for sarcopenia prevention.

Keywords: Muscle atrophy; Muscle regeneration; Natural resources; Sarcopenia; Signaling pathway.

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Conflict of interest statement

Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic diagram of the signaling pathways involved in skeletal muscle mass loss.
See this image and copyright information in PMC

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