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. 2024;13(3):325-336.
doi: 10.22088/IJMCM.BUMS.13.3.325.

Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease

Rosita Azar Bahadori  1 , Dina Shabani  2 , Elham Arjmandrad  3 , Mahsa Kazerani  4 , Mina Rohani  5 , Zohreh Ramazani Karim  6 , Masoud Ali-Kheyl  6 , Reza Nosratabadi  7 , Hossein Pourghadamyari  8 , Mohammad Ali Zaemi  9
Affiliations

Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease

Rosita Azar Bahadori et al. Int J Mol Cell Med. 2024.

Abstract

Coronary artery diseases (CAD) represent a significant global health concern and are recognized as a primary contributor to mortality on a worldwide scale. Early diagnosis of CAD is one of promising goal to manage this disorder. Recent investigations have highlighted the pivotal involvement of microRNAs (miRNAs) in diverse health conditions, notably CAD. The principal objective of this investigation was to identify appropriate miRNAs that could be employed for the early detection of CAD. In the present study, we analyzed dataset of CAD (GSE113079) and 100 differentially expressed mRNAs (DEmRNAs) were detected. The miRNAs that have a significant interaction with DEmRNAs were chosen. By computational prediction method, 5 miRNAs (miR-106b-5p, miR-20a-3p, miR-17-3p, miR-146a-5p, and miR-155-3p) were selected. Finally, we assessed the anticipated expression levels of microRNAs in CAD patients and healthy control groups. Our findings revealed a statistically significant elevation solely in the expression level of miR-106b-5p within the CAD group when compared to the control group (p>0.001). Our study demonstrated an elevation in the expression of miR-106b-5p in individuals diagnosed with CAD. This microRNA may be used as a diagnostic biomarker in patients with CAD. However, further investigations are needed to confirm these results.

Keywords: MicroRNA; coronary artery disease; miRNA-mRNA intraction; qRT-PCR.

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Figures

Fig. 1
Fig. 1
miRNA-mRNA interaction network, green diamonds represent miRNAs and red circles represent Up-DEmRNAs in this study.
Fig. 2
Fig. 2
GSEA analysis for targets of top DEmRNAs.
Fig. 3
Fig. 3
Comparison of the expression levels of serum (A) miR-106b-5p, (B) miR-155-3p, (C) miR-17-3p, (D) miR-20a-3p and (F) miR-146a-5p in CAD patients and healthy groups. CAD: Coronary artery disease. (*> 0.05, **> 0.01, ***> 0.001)
Fig. 4
Fig. 4
Receiver operating characteristic (ROC) curve analysis of has-miR-106b-5p to discriminate CAD patients from healthy controls.
See this image and copyright information in PMC

References

    1. Foroughinia F, Dehghani P, Dianatpour M, et al. The association between estrogen receptor 2 gene polymorphism and complexity of coronary artery disease: an analysis in elective percutaneous coronary intervention patients. BMC Cardiovasc Disord. 2021;21:275. - PMC - PubMed
    1. Xiao J, Yong JN, Ng CH, et al. A Meta-Analysis and Systematic Review on the Global Prevalence, Risk Factors, and Outcomes of Coronary Artery Disease in Liver Transplantation Recipients. Liver Transpl. 2022;28:689–99. - PubMed
    1. Polsook R, Aungsuroch Y. A cross-sectional study of factors predicting readmission in Thais with coronary artery disease. J Res Nurs. 2021;26:293–304. - PMC - PubMed
    1. Liu Q, Piao H, Wang Y, et al. Circulating exosomes in cardiovascular disease: Novel carriers of biological information. Biomed Pharmacother. 2021;135:111148. - PubMed
    1. Bahbah EI, Noehammer C, Pulverer W, et al. Salivary biomarkers in cardiovascular disease: An insight into the current evidence. FEBS J. 2021;288:6392–405. - PubMed

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