Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;57(2):143-8.
doi: 10.1007/BF00381382.

Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane

N Fedtke, H M Bolt

Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane

N Fedtke et al. Int Arch Occup Environ Health. 1986.

Abstract

The neurotoxic n-hexane metabolite 2,5-hexanedione was detected by gas chromatography--mass spectrometry in urine samples from human subjects not exposed to n-hexane or related hydrocarbons. Quantitative determinations by multiple ion detection revealed an amount of 2,5-hexanedione ranging from 0.12 to 0.78 mg/l (0.45 +/- 0.20 mg/l; means +/- SD). The amounts of 2,5-hexanedione actually measured in urinary extracts depended on the pH employed for acid hydrolysis of the samples.

PubMed Disclaimer

References

    1. Br J Ind Med. 1981 Feb;38(1):20-6 - PubMed
    1. Life Sci. 1980 Sep 1;27(9):731-8 - PubMed
    1. Br J Ind Med. 1984 Nov;41(4):533-8 - PubMed
    1. Int Arch Occup Environ Health. 1986;57(2):149-58 - PubMed
    1. Science. 1974 Aug 30;185(4153):787-9 - PubMed