Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: a systematic review and meta-analysis

Abstract

Background: The aim of this systematic review and meta-analysis was to furnish evidence-based recommendations for the utilization of bioceramic-based and resin-based sealers in clinical endodontics, with a focus on reducing postoperative discomfort.

Methods: The investigation's methodology was registered on the International Prospective Database of Systematic Reviews (PROSPERO: CRD42022355506) and executed using the 2020 PRISMA protocol. Articles were selected utilizing the PICO technique and applying specific inclusion and exclusion criteria. Articles published between January 2000 and August 2022, PubMed, MEDLINE, and DOAJ were utilized as primary data sources. After the identification of studies, two autonomous reviewers evaluated the titles and abstracts, and data from qualifying studies were extracted.

Results: Nine published studies were included in this analysis. The findings indicate that there were no significant differences in the Visual Analog Scale (VAS) scores between resin-based and bioceramic root canal sealers at intervals of 6 hours, 12 hours, 24 hours, and 48 hours after treatment.

Conclusion: The findings of this systematic review and meta-analysis suggest that after the utilization of bioceramic sealers during root canal therapy, the pain and discomfort levels were not significantly different from those experienced pain after the use of resin-based sealers.

Keywords: Bioceramic sealers; Discomfort; Meta-analysis; Pain; Resin-based sealers; Root canal therapy; Systematic review.

Figure 1. PRISMA flow diagram.

Figure 2. Risk of bias graph of the included studies.

Figure 3. Risk of bias assessment of the included studies.

Figure 4. Forest plot for post-operative pain score between the groups after six hours of treatment.

Note: See Atav Ates et al. (2019) and Khatri et al. (2022).

Figure 5. Forest plot for Post-operative pain score between the groups after 12 h of treatment.

Note: See Atav Ates et al. (2019) and Khatri et al. (2022).

Figure 6. Forest plot for post-operative pain score between the groups after 24 h of treatment.

Note: See Atav Ates et al. (2019), Fonseca et al. (2019), Graunaite et al. (2018), Khandelwal et al. (2022) and Khatri et al. (2022).

Figure 7. Forest plot for post-operative pain score between the groups after 48 h of treatment.

Note: See Fonseca et al. (2019), Graunaite et al. (2018), Khandelwal et al. (2022) and Khatri et al. (2022).

Figure 8. Forest plot comparing the intake of analgesics after 24 h of treatment.

Note: See Fonseca et al. (2019), Graunaite et al. (2018), Khandelwal et al. (2022) and Khatri et al. (2022).