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. 2024 Oct 18:37:13142.
doi: 10.3389/ti.2024.13142. eCollection 2024.

Promising Results of Kidney Transplantation From Donors Following Euthanasia During 10-Year Follow-Up: A Nationwide Cohort Study

Charlotte Susanna  1   2 , Nathalie van Dijk  1 , Wim de Jongh  2 , Hanne Verberght  2   3   4 , Walther van Mook  1   5   6 , Jan Bollen  7 , Bas van Bussel  1   8   9
Affiliations

Promising Results of Kidney Transplantation From Donors Following Euthanasia During 10-Year Follow-Up: A Nationwide Cohort Study

Charlotte Susanna et al. Transpl Int. .

Abstract

The outcome of kidneys transplanted following organ donation after euthanasia (ODE) remains unclear. This study analyzed all kidney transplantations in the Netherlands from January 2012 to December 2021, comparing the outcomes following ODE, donation after circulatory death (DCD-III), and donation after brain death (DBD). 9,208 kidney transplantations were performed: 148 ODE, 2118 DCD-III, and 1845 DBD. Initial graft function was compared between these categories. Immediate graft function, delayed graft function and primary non-function in ODE kidney recipients were 76%, 22%, and 2%, respectively, 47%, 50% and 3% in DCD-III kidney recipients and 73%, 25%, and 2% in DBD kidney recipients (overall p-value: p < 0.001). The number of kidneys transplanted over a median follow-up period of 4.0 years (IQR 2.0-6.6), was 1810, including 72 ODE, 958 DCD-III and 780 DBD kidneys. In this period, 213 grafts (11.8%) failed [7 grafts (9.7%) from ODE donors, 93 grafts (9.7%) from DCD-III donors, and 113 grafts (14.5%) from DBD donors]. Kidneys transplanted after euthanasia have a good immediate graft function, a comparable longitudinal 10 years eGFR, and similar graft failure hazard to kidneys from DCD-III and DBD. Kidney transplantation following ODE is a valuable and safe contribution to the donor pool.

Keywords: donation after brain death; donation after circulatory death; euthanasia; kidney transplantation; medical assistance in dying; organ donation; organdonation after euthanasia; physician assisted death.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

None
Graphical abstract
FIGURE 1
FIGURE 1
Flowchart of transplantation inclusions and exclusions.
See this image and copyright information in PMC

References

    1. Kootstra G, Daemen JH, Oomen AP. Categories of Non-Heart-Beating Donors. Transpl Proc (1995) 27(5):2893–4. - PubMed
    1. Kootstra G, van Heurn E. Non-Heartbeating Donation of Kidneys for Transplantation. Nat Clin Pract Nephrol (2007) 3(3):154–63. 10.1038/ncpneph0426 - DOI - PubMed
    1. Detry O, Le Dinh H, Noterdaeme T, De Roover A, Honore P, Squifflet JP, et al. Categories of Donation After Cardiocirculatory Death. Transpl Proc (2012) 44(5):1189–95. 10.1016/j.transproceed.2012.05.001 - DOI - PubMed
    1. Bollen J, de Jongh W, Hagenaars J, van Dijk G, ten Hoopen R, Ysebaert D, et al. Organ Donation After Euthanasia: A Dutch Practical Manual. Am J Transplant (2016) 16(7):1967–72. 10.1111/ajt.13746 - DOI - PubMed
    1. Silva ESV, Silva AR, Rochon A, Lotherington K, Hornby L, Wind T, et al. Organ Donation Following Medical Assistance in Dying, Part II: A Scoping Review of Existing Processes and Procedures. JBI Evid Synth (2024) 22(2):195–233. 10.11124/jbies-22-00140 - DOI - PMC - PubMed