Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 5;150(19):1560-1562.
doi: 10.1161/CIRCULATIONAHA.123.067470. Epub 2024 Nov 4.

Association of Echocardiographic Parameters and Health Status in Patients With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM

Affiliations

Association of Echocardiographic Parameters and Health Status in Patients With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM

Suzanne V Arnold et al. Circulation. .
No abstract available

Keywords: cardiomyopathy, hypertrophic; health status; heart failure, diastolic; quality of life.

PubMed Disclaimer

Conflict of interest statement

Dr Dolan reports consultant fees from MyoKardia, Genentech, Puma Biotechnology, Gilead Sciences, Alexion Pharmaceuticals, Portola Pharmaceuticals, Halozyme Therapeutics, Global Blood Therapeutics, and REGENXBIO. Dr Fine is an employee of Bristol Myers Squibb at the time of this article development; and reports stock and stock options from the company. Dr Masri reports research grants from Pfizer, Akcea, Ionis, Ultromics, and the Wheeler Foundation; as well as fees (consulting or honoraria) from Eidos, Pfizer, Ionis, Bristol Myers Squibb, Attralus, Tenaya, Alnylam, and Cytokinetics. Dr Saberi reports consulting fees from MyoKardia and Cytokinetics. Dr Wang reports consultant fees from MyoKardia and personal fees from Cytokinetics. Dr Elliot reports consultant and personal fees from MyoKardia, Sanofi, AstraZeneca, Pfizer, and DinaQor; and patent No. GB1815111.8 issued to his institution. Dr Hegde reports that her institution received payments for her consulting work from MyoKardia. Drs Lam and Sehnert are employees of Bristol Myers Squibb and report stock and stock options from the company. Dr Cresci reports that her institution received clinical trial funding from Imbria Pharmaceuticals; and membership on the Data Monitoring Committee for Cytokinetics. Dr Bach reports institutional funding for clinical trials by MyoKardia/Bristol Myers Squibb and Cytokinetics. Dr Spertus reports consultative services on patient-reported outcomes and evidence evaluation for Alnylam, AstraZeneca, Bayer, Merck, Janssen, Bristol Meyers Squibb, Edwards, Kineksia, 4DT Medical, Terumo, Cytokinetics, Imbria, and United Healthcare. He holds research grants from Bristol Meyers Squibb, Abbott Vascular, and Janssen. He owns the copyright to the Seattle Angina Questionnaire, Kansas City Cardiomyopathy Questionnaire, and Peripheral Artery Questionnaire and serves on the Board of Directors for Blue Cross Blue Shield of Kansas City. The other authors report no disclosures.

Figures

Figure.
Figure.
Association of change in echocardiographic parameter with change in KCCQ-OS from baseline to 30 weeks. A, Peak LVOT gradient at rest. B, Peak left ventricular outflow gradient with Valsalva. C, Peak LVOT gradient postexercise. D, Interventricular septum wall thickness. Solid lines represent the expected changes in KCCQ-OS per unit change in echocardiographic parameter. Dotted lines represent 95% CI around that estimate. P values reflect the statistical significance of the association of each echocardiographic change parameter with change in KCCQ-OS. All models adjusted for baseline KCCQ-OS and baseline echocardiographic parameter; restricted cubic splines tested for nonlinearity and only significant for IVST (P=0.019). Echocardiographic parameters for which changes were not significantly associated with changes in KCCQ-OS included: LV ejection fraction (P =0.12), LV stroke volume (LV end-diastolic volume – LV end-systolic volume; P =0.99), E/e’ septal (P=0.71), E/e’ lateral (P=0.64), E/e’ average (P=0.64), left atrial volume index (P =0.20), posterior wall thickness (P=0.07), relative wall thickness (P=0.29), and resolution of systolic anterior motion of the mitral valve (P=0.41). IVST indicates interventricular septum thickness; KCCQ-OS, Kansas City Cardiomyopathy Questionnaire–Overall Summary score; LV, left ventricular; and LVOT, left ventricular outflow tract.

References

    1. Hegde SM, Lester SJ, Solomon SD, Michels M, Elliott PM, Nagueh SF, Choudhury L, Zemanek D, Zwas DR, Jacoby D, et al. . Effect of mavacamten on echocardiographic features in symptomatic patients with obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol. 2021;78:2518–2532. doi: 10.1016/j.jacc.2021.09.1381 - PubMed
    1. Olivotto I, Oreziak A, Barriales-Villa R, Abraham TP, Masri A, Garcia-Pavia P, Saberi S, Lakdawala NK, Wheeler MT, Owens A, et al. ; EXPLORER-HCM study investigators. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2020;396:759–769. doi: 10.1016/S0140-6736(20)31792-X - PubMed
    1. Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, Saberi S, Li W, Dolan C, Reaney M, Sehnert AJ, et al. . Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2021;397:2467–2475. doi: 10.1016/S0140-6736(21)00763-7 - PubMed
    1. Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000;35:1245–1255. doi: 10.1016/s0735-1097(00)00531-3 - PubMed
    1. Nassif M, Fine JT, Dolan C, Reaney M, Addepalli P, Allen VD, Sehnert AJ, Gosch K, Spertus JA. Validation of the Kansas City Cardiomyopathy Questionnaire in symptomatic obstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2022;10:531–539. doi: 10.1016/j.jchf.2022.03.002 - PubMed

Associated data

LinkOut - more resources