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. 2025 Apr 1;84(4):356-359.
doi: 10.1093/jnen/nlae116.

Star-shaped TDP-43 inclusions in the oldest-old

Erin E Connolly  1 , John F Ervin  1 , Brenda L Plassman  2 , Kathleen A Welsh-Bohmer  2 , Shih-Hsiu J Wang  1   3
Affiliations

Star-shaped TDP-43 inclusions in the oldest-old

Erin E Connolly et al. J Neuropathol Exp Neurol. .
No abstract available

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
(A) Whole slide imaging of a section of the amygdala stained with H&E; areas of the amygdala with star-shaped TDP-43 inclusions are indicated by the yellow boxes. (B) Diagram showing the anatomical subdivisions of the amygdala at the level shown in (A). (C) Whole slide imaging of a section of the amygdala stained with phosphorylated tau (AT8) immunohistochemistry. (C-F) ARTAG was identified with tau (AT8) immunohistochemistry. Extensive ARTAG was seen in the amygdala and entorhinal cortex (C, D), including numerous thorn-shaped astrocytes (E) and granular fuzzy astrocytes (F). (G-J) Star-shaped TDP-43 inclusions were identified with pTDP-43 immunohistochemistry. These include lesions with TDP-43 deposition in the perinuclear cytoplasm and proximal processes (G), granular pattern of staining in the distal processes with minimal accumulation in the cell bodies (H), and ring-like or comma-shaped staining resembling oligodendroglial coiled bodies (I). Beyond the amygdala, there were focal areas with dot-like TDP-43 staining in the subependymal regions of the fimbriae and subiculum of the hippocampus (J). (K, L) No TDP-43 inclusions were identified with cTDP-43 immunohistochemistry (K). Negative control for cTDP-43 immunohistochemistry using secondary antibody alone (L). Positive control for cTDP-43 immunohistochemistry using frontal cortex from a subject with FTLD-TDP showing a neuron with nuclear clearing and cytoplasmic inclusion (L'). Scale bars: A, C = 4 mm, D = 400 µm, E-J = 40 µm, K-L = 80 µm, L' = 20 µm. Abbreviations: ARTAG = age-related tau astrogliopathy; CoA = cortico-amygdaloid transition area; AAA = anterior amygdaloid area; BLC = basolateral complex; WM = white matter; ENT = entorhinal cortex; TENT = transentorhinal cortex.
See this image and copyright information in PMC

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