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. 1986 Feb;22(2):107-12.
doi: 10.1007/BF02623540.

Endoderm-secreted factor stimulates growth of embryonal carcinoma stem cells

E L Germain, J W Littlefield

Endoderm-secreted factor stimulates growth of embryonal carcinoma stem cells

E L Germain et al. In Vitro Cell Dev Biol. 1986 Feb.

Abstract

Stem cells of the embryonal carcinoma cell line called H6 can be induced to differentiate to endoderm-like cells by retinoic acid (3 X 10(-6) M). We have detected a diffusible and stable factor which is secreted by H6 endoderm-like cells and stimulates the growth of H6 stem cells. The stimulation by the endoderm-like cells is considerably greater than that by mouse fibroblasts or H6 stem cells themselves. No reciprocal stimulation of endoderm-like cells by stem cells occurs. Part but not all of the stimulation might be due to extracellular matrix proteins or to insulin-like growth factor type 2, each of which also stimulates the growth of H6 stem cells. Insulin causes no such stimulation.

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