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. 2024 Dec;40(12):1077-1080.
doi: 10.1016/j.pt.2024.10.008. Epub 2024 Nov 4.

A hypothesis to explain malaria-induced neurocognitive sequelae

Yuri Chaves Martins  1 , Cláudio Tadeu Daniel-Ribeiro  2
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Free article

A hypothesis to explain malaria-induced neurocognitive sequelae

Yuri Chaves Martins et al. Trends Parasitol. 2024 Dec.
Free article

Abstract

The development of malaria-induced neurocognitive and behavioral sequelae is not entirely understood. We hypothesize that liver dysfunction caused by Plasmodium infection is responsible for malaria-induced neurocognitive and behavioral sequelae. Our metabolic hypothesis not only explains neurocognitive sequelae after cerebral malaria (CM) but also after other severe, non-severe, and asymptomatic malaria infections.

Keywords: acute liver failure; cerebral malaria; malaria pathogenesis; neurocognitive and behavioral sequelae; neurotoxicity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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