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Review
. 2025 Jan 2;26(1):e202400719.
doi: 10.1002/cbic.202400719. Epub 2024 Nov 23.

Reprogramming of Glucose Metabolism for Revisiting Hepatocellular Carcinoma Resistance to Transcatheter Hepatic Arterial Chemoembolization

Ruijie Zhang  1 , Fan Dai  1 , Songhan Deng  2 , Yun Zeng  1 , Jinyang Wang  1 , Gang Liu  1
Affiliations
Review

Reprogramming of Glucose Metabolism for Revisiting Hepatocellular Carcinoma Resistance to Transcatheter Hepatic Arterial Chemoembolization

Ruijie Zhang et al. Chembiochem. .

Abstract

Hepatocellular carcinoma (HCC) is recognized globally as one of the most lethal tumors, presenting a significant menace to patients' lives owing to its exceptional aggressiveness and tendency to recur. Transcatheter hepatic arterial chemoembolization (TACE) therapy, as a first-line treatment option for patients with advanced HCC, has been proven effective. However, it is disheartening that nearly 40 % of patients exhibit resistance to this therapy. Consequently, this review delves into the metabolic aspects of glucose metabolism to explore the underlying mechanisms behind TACE treatment resistance and to propose potentially fruitful therapeutic strategies. The ultimate objective is to present novel insights for the development of personalized treatment methods targeting HCC.

Keywords: Glucose metabolism; Hepatocellular carcinoma; TACE treatment resistance.

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