Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;34(11):e14757.
doi: 10.1111/sms.14757.

Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study

Koen M van der Sluijs  1 , Esmée A Bakker  1   2 , Thijs P Kerstens  1 , Niels A Stens  1   3 , Iris A de Koning  1 , Jos Thannhauser  1   3 , Afrah E F Malik  4 , Koen D Reesink  4 , P M Nabeel  5 , Kiran V Raj  5 , Jayaraj Joseph  6 ; Nijmegen Exercise Study collaboration  1 ; Thijs M H Eijsvogels  1 , Dick H J Thijssen  1
Collaborators, Affiliations

Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study

Koen M van der Sluijs et al. Scand J Med Sci Sports. 2024 Nov.

Abstract

Sedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this association. We recruited adult volunteers and measured SB with thigh-worn accelerometery for 24 hrs/day for eight consecutive days. Central (carotid-femoral pulse wave velocity, cfPWV, gold standard) and local carotid arterial stiffness (stiffness index Beta and pressure-strain elasticity EP) were measured with ultrasound. Linear regression was used and adjusted for demographics, cardiometabolic factors, and moderate-to-vigorous physical activity (MVPA) volume. Effect modification was studied with interaction terms. Participants (N = 664, 64 (standard deviation: 11, range: 23-89) years, 397 (59.8%) male) demonstrated 9.1 (1.6) hrs/day of SB, and arterial stiffness was 8.6 (3.0) m/s for cfPWV, 6.4 (2.9) for Beta, and 87 (43) kPa for EP. SB was not associated with cfPWV (β = 0.04 95% CI (-0.11, 0.18), p = 0.60). The association of SB with local arterial stiffness was modified by systolic blood pressure (SBP) and MVPA volume. Stratified analyses revealed positive associations of SB with Beta (β = 0.29 (0.05, 0.53), p = 0.016) and EP (β = 4.83 (1.39, 8.27), p = 0.006) in participants with SBP > 134 mmHg or > 103 min/day of MVPA (β = 0.23 (0.03, 0.42), p = 0.024 and β = 3.55 (0.82, 6.29), p = 0.011, respectively). We found no association of objectively measured SB with central arterial stiffness. However, SB was positively associated with local carotid stiffness in participants with higher SBP or MVPA levels. In certain subgroups, SB may affect carotid arterial stiffening, reinforcing the relation between SB and cardiovascular disease.

Keywords: arterial stiffness; cardiovascular disease; pulse wave velocity; sedentary behavior; thigh‐worn accelerometery.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. A. Biswas, P. I. Oh, G. E. Faulkner, et al., “Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults: A Systematic Review and Meta‐Analysis,” Annals of Internal Medicine 162, no. 2 (2015): 123–132, https://doi.org/10.7326/m14‐1651.
    1. R. Patterson, E. McNamara, M. Tainio, et al., “Sedentary Behaviour and Risk of All‐Cause, Cardiovascular and Cancer Mortality, and Incident Type 2 Diabetes: A Systematic Review and Dose Response Meta‐Analysis,” European Journal of Epidemiology 33, no. 9 (2018): 811–829, https://doi.org/10.1007/s10654‐018‐0380‐1.
    1. E. Stamatakis, J. Gale, A. Bauman, U. Ekelund, M. Hamer, and D. Ding, “Sitting Time, Physical Activity, and Risk of Mortality in Adults,” Journal of the American College of Cardiology 73, no. 16 (2019): 2062–2072, https://doi.org/10.1016/j.jacc.2019.02.031.
    1. U. Ekelund, J. Tarp, J. Steene‐Johannessen, et al., “Dose‐Response Associations Between Accelerometry Measured Physical Activity and Sedentary Time and All Cause Mortality: Systematic Review and Harmonised Meta‐Analysis,” BMJ 366 (2019): l4570, https://doi.org/10.1136/bmj.l4570.
    1. F. C. Bull, S. S. Al‐Ansari, S. Biddle, et al., “World Health Organization 2020 Guidelines on Physical Activity and Sedentary Behaviour,” British Journal of Sports Medicine 54, no. 24 (2020): 1451–1462, https://doi.org/10.1136/bjsports‐2020‐102955.

LinkOut - more resources