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Editorial
. 2024 Aug 29:9:54.
doi: 10.21037/tgh-24-48. eCollection 2024.

KRAS G12C inhibitors in metastatic colorectal cancer: a tale of two targets

Affiliations
Editorial

KRAS G12C inhibitors in metastatic colorectal cancer: a tale of two targets

Julia Martínez-Pérez et al. Transl Gastroenterol Hepatol. .
No abstract available

Keywords: KRAS G12C; Metastatic colorectal cancer (mCRC); RAS-mutant; epidermal growth factor receptor (EGFR); target therapy.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-24-48/coif). J.M.P. received honoraria and support for attending meetings and travel from Bristol-Myers Squibb, Merck Sharp & Dohme Corp, and Merck. M.V.A. received contracts from AMGEN (Research contract, personal fees) and ROCHE (Research contract, Institutional); consulting fees from AMGEN, SERVIER, and SANOFI; payment from MSD, Bristol-Myers, and Merck; support for attending meetings and travel from Merck, SERVIER, and AMGEN; and is the member on Advisory Board from AMGEN, SERVIER, and MERCK. The authors have no other conflicts of interest to declare.

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References

    1. Canon J, Rex K, Saiki AY, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature 2019;575:217-23. 10.1038/s41586-019-1694-1 - DOI - PubMed
    1. Hong DS, Fakih MG, Strickler JH, et al. KRAS(G12C) Inhibition with Sotorasib in Advanced Solid Tumors. N Engl J Med 2020;383:1207-17. 10.1056/NEJMoa1917239 - DOI - PMC - PubMed
    1. Fakih M, Tu H, Hsu H, et al. Real-World Study of Characteristics and Treatment Outcomes Among Patients with KRAS p.G12C-Mutated or Other KRAS Mutated Metastatic Colorectal Cancer. Oncologist 2022;27:663-74. 10.1093/oncolo/oyac077 - DOI - PMC - PubMed
    1. Henry JT, Coker O, Chowdhury S, et al. Comprehensive Clinical and Molecular Characterization of KRAS (G12C)-Mutant Colorectal Cancer. JCO Precis Oncol 2021;5:PO.20.00256. - PMC - PubMed
    1. Osterlund E, Ristimäki A, Kytölä S, et al. KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer. Front Oncol 2022;12:826073. 10.3389/fonc.2022.826073 - DOI - PMC - PubMed

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