KRAS G12C inhibitors in metastatic colorectal cancer: a tale of two targets
- PMID: 39503027
- PMCID: PMC11535810
- DOI: 10.21037/tgh-24-48
KRAS G12C inhibitors in metastatic colorectal cancer: a tale of two targets
Keywords: KRAS G12C; Metastatic colorectal cancer (mCRC); RAS-mutant; epidermal growth factor receptor (EGFR); target therapy.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-24-48/coif). J.M.P. received honoraria and support for attending meetings and travel from Bristol-Myers Squibb, Merck Sharp & Dohme Corp, and Merck. M.V.A. received contracts from AMGEN (Research contract, personal fees) and ROCHE (Research contract, Institutional); consulting fees from AMGEN, SERVIER, and SANOFI; payment from MSD, Bristol-Myers, and Merck; support for attending meetings and travel from Merck, SERVIER, and AMGEN; and is the member on Advisory Board from AMGEN, SERVIER, and MERCK. The authors have no other conflicts of interest to declare.
Comment on
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Sotorasib with panitumumab in chemotherapy-refractory KRASG12C-mutated colorectal cancer: a phase 1b trial.Nat Med. 2024 Jan;30(1):265-270. doi: 10.1038/s41591-023-02717-6. Epub 2024 Jan 4. Nat Med. 2024. PMID: 38177853 Free PMC article. Clinical Trial.
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