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. 2025 Mar;42(1):12-26.
doi: 10.1111/ger.12783. Epub 2024 Nov 6.

Natural products for denture base disinfection: A scoping review

Bianca Lopes de Andrade Martins de Lima  1 , Jeferson Batista Santiago  1 , Maria Eduarda Lemos Avelino  1 , Taciana Emília Leite Vila-Nova  1 , Rayanna Thayse Florêncio Costa  1 , Sandra Lúcia Dantas Moraes  1
Affiliations

Natural products for denture base disinfection: A scoping review

Bianca Lopes de Andrade Martins de Lima et al. Gerodontology. 2025 Mar.

Abstract

Objective: This study aims to map the existing literature on natural products used as disinfection substances for conventional polymethyl methacrylate (PMMA) and computer-aided design and manufacturing (CAD-CAM) dentures.

Background: Denture wearers are at high risk for denture stomatitis. Natural products have attracted the interest of the scientific community as an alternative to synthetic ones.

Materials and methods: The guiding question "Which natural products have been applied to disinfect complete dentures in conventional PMMA or CAD-CAM PMMA resin?" Searches were conducted in the PubMed/MEDLINE, Embase, Web of Science, and Cochrane databases, and manual searches were performed in reference journals in the area with studies published until December 2023, without language or date restrictions.

Results: A total of 4272 articles were identified, and 46 studies were included after applying the eligibility criteria. Thirty-nine natural products were evaluated. Of the included studies, 43 presented positive findings and three obtained negative findings on the effectiveness of natural products in inhibiting or killing Candida albicans.

Conclusion: Natural products, predominantly sourced from the Plantae kingdom, have demonstrated efficacy in reducing Candida albicans on the surface of conventional PMMA. However, the evidence primarily stems from in vitro studies, underscoring the necessity for additional clinical research to validate their applicability under real microbiological conditions in prosthesis users.

Keywords: Candida albicans; CAD‐CAM; PMMA; natural products.

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References

REFERENCES

    1. Badaró M, Salles M, Leite V, Arruda C. Clinical trial for evaluation of Ricinus communis and sodium hypochlorite as denture cleanser. J Appl Oral Sci. 2017;25(3):324‐334.
    1. Dalwai S, Rodrigues SJ, Baliga S, et al. Comparative evaluation of antifungal action of tea tree oil, chlorhexidine gluconate and fluconazole on heat polymerized acrylic denture base resin – an in vitro study. Gerodontology. 2016;33:402‐409.
    1. Meriç G, Meryem Guvenir KS. Evaluating the efficiency of humic acid micro‐organisms from denture base material. Gerodontology. 2014;33:1‐7.
    1. de Almeida L, De Dantas F, de Paula JF, et al. Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms. Acta Odontol Scand. 2016;74:393‐398.
    1. Gulce Çakmak MBD. Effect of thermocycling on the flexural strength and hardness of new‐generation denture base materials. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and pr. 2022;3–19.

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