Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 3;84(23):2308-2324.
doi: 10.1016/j.jacc.2024.09.016. Epub 2024 Nov 6.

Sudden Death in Obesity: Mechanisms and Management

Lauri Holmstrom  1 , Juhani Junttila  2 , Sumeet S Chugh  3
Affiliations
Review

Sudden Death in Obesity: Mechanisms and Management

Lauri Holmstrom et al. J Am Coll Cardiol. .

Abstract

In recent decades, the prevalence of obesity has increased significantly, leading to an epidemic at the global level. Obesity is associated with various metabolic alterations and increases the risk of cardiovascular disease. The most devastating manifestation of cardiovascular disease is sudden cardiac death (SCD), leading to substantial years of potential life lost worldwide. Obesity-related SCD is an increasingly important public health problem and warrants a specific investigative focus on improved risk stratification and prevention. In this review, we summarize the current evidence regarding management of SCD in obesity and discuss knowledge gaps as well as future directions in this field.

Keywords: coronary artery disease; epidemiology; hypertrophy; obesity; sudden death.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures Obesity related studies at the University of Oulu are supported by Profi6 Fibrobesity programme of Research Council of Finland Decision 336449, and also by the Inkeri and Mauri Vänskä Foundation. Dr Holmstrom is a postdoctoral fellow at the Cedar-Sinai Center for Cardiac Arrest Prevention, visiting from the Research Unit of Internal Medicine, Medical Research Center Oulu, the University of Oulu and Oulu University Hospital, Oulu, Finland; and was funded by Sigrid Juselius Foundation, The Finnish Cultural Foundation, Instrumentarium Science Foundation, Orion Research Foundation, and Paavo Nurmi Foundation. Dr Junttila has received grants from the Sigrid Juselius Foundation, Finnish Foundation for Cardiovascular Research, and Research Council of Finland (grant 363981). Dr Chugh has received grants from the National Heart, Lung, and Blood Institute (grants R01HL145675 and R01HL147358).

MeSH terms

LinkOut - more resources