Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome

Ranxi Chen^{1

2

3}, Shuhui Xie^{2

3

4}, Jin Gao^{5

6}, Shuli Zhang^{7

8}, Xiaobin Zhang^{5

9}, Yi Yao^{3

5

9}, Gengxiu Zheng¹⁰, Fengpeng Wang^{11

12}, Zili Liu^{13

14

15}, Xuefeng Shen^{16

17

18}

Affiliations

¹ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.
² CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China.
³ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China.
⁴ Sino-Danish College, University of CAS, Beijing, 100190, China.
⁵ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China.
⁶ Department of Pathology, XHH, Xiamen, 361003, China.
⁷ State Key Laboratory of Brain and Cognitive Sciences, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, CAS, Beijing, 100101, China.
⁸ University of CAS, Beijing, 100049, China.
⁹ Epilepsy Center, XHH, Xiamen, 361003, China.
¹⁰ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China. chm_zhenggx@ujn.edu.cn.
¹¹ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. fengpeng_wang@163.com.
¹² Epilepsy Center, XHH, Xiamen, 361003, China. fengpeng_wang@163.com.
¹³ CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. zl.liu@siat.ac.cn.
¹⁴ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China. zl.liu@siat.ac.cn.
¹⁵ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. zl.liu@siat.ac.cn.
¹⁶ CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. xf.shen@siat.ac.cn.
¹⁷ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China. xf.shen@siat.ac.cn.
¹⁸ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. xf.shen@siat.ac.cn.

PMID: 39503967
PMCID: PMC11876502 (available on 2026-03-01)
DOI: 10.1007/s12264-024-01311-1

Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome

Ranxi Chen et al. Neurosci Bull. 2025 Mar.

. 2025 Mar;41(3):520-524.

doi: 10.1007/s12264-024-01311-1. Epub 2024 Nov 6.

Authors

Affiliations

¹ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.
² CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China.
³ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China.
⁴ Sino-Danish College, University of CAS, Beijing, 100190, China.
⁵ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China.
⁶ Department of Pathology, XHH, Xiamen, 361003, China.
⁷ State Key Laboratory of Brain and Cognitive Sciences, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, CAS, Beijing, 100101, China.
⁸ University of CAS, Beijing, 100049, China.
⁹ Epilepsy Center, XHH, Xiamen, 361003, China.
¹⁰ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China. chm_zhenggx@ujn.edu.cn.
¹¹ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. fengpeng_wang@163.com.
¹² Epilepsy Center, XHH, Xiamen, 361003, China. fengpeng_wang@163.com.
¹³ CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. zl.liu@siat.ac.cn.
¹⁴ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China. zl.liu@siat.ac.cn.
¹⁵ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. zl.liu@siat.ac.cn.
¹⁶ CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China. xf.shen@siat.ac.cn.
¹⁷ The Brain Cognition and Brain Disease Institute, SIAT, CAS, Shenzhen, 518055, China. xf.shen@siat.ac.cn.
¹⁸ HH-SIAT Joint Center for Epilepsy Research, Xiamen Humanity Hospital (XHH), Xiamen, 361003, China. xf.shen@siat.ac.cn.

PMID: 39503967
PMCID: PMC11876502 (available on 2026-03-01)
DOI: 10.1007/s12264-024-01311-1

No abstract available

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Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

References

1. Yeom S, Comi AM. Updates on sturge-weber syndrome. Stroke 2022, 53: 3769–3779. - PMC - PubMed
1. Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B. Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 2013, 368: 1971–1979. - PMC - PubMed
1. Rihani HT, Dalvin LA, Hodge DO, Pulido JS. Incidence of Sturge-Weber syndrome and associated ocular involvement in Olmsted County, Minnesota, United States. Ophthalmic Genet 2020, 41: 108–124. - PMC - PubMed
1. Wang S, Pan J, Zhao M, Wang X, Zhang C, Li T, et al. Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome. Brain 2022, 145: 3431–3443. - PubMed
1. Xu X, Sun H, Luo J, Cheng X, Lv W, Luo W, et al. The pathology of primary familial brain calcification: Implications for treatment. Neurosci Bull 2023, 39: 659–674. - PMC - PubMed

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Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome

Affiliations

Vascular Ossification in the Developing Brain: A Case Study of Pediatric Sturge Weber Syndrome

Authors

Affiliations

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources