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. 2024 Nov 4:57:e14301.
doi: 10.1590/1414-431X2024e14301. eCollection 2024.

Evaluation of COVID-19 cases treated in the intensive care unit in a coastal city hospital during the pandemic

P H A Klauss  1   2 , E M B Hi  1   2 , C C R Bianchi  1   2 , A U Ruiz  3 , M F C B de Barros  1 , B M da Silva  2 , T L Moretto  2 , F G Soriano  1 , R Curi  4   5 , M C C Machado  1 , R B Gritte  1
Affiliations

Evaluation of COVID-19 cases treated in the intensive care unit in a coastal city hospital during the pandemic

P H A Klauss et al. Braz J Med Biol Res. .

Abstract

SARS-CoV-2 is a novel coronavirus that infects the respiratory tract and was the causing agent of COVID-19, declared a pandemic by the World Health Organization on March 11, 2020. Several studies have been carried out to understand the pathophysiology of the disease, immune reactions, and risk factors that could aggravate the condition and predict the prognosis of patients. Therefore, this study aimed to evaluate the most prevalent laboratory data of hospitalized patients associated with discharge or death. A survey was conducted utilizing the medical records of COVID-19 cases in patients treated in the intensive care unit of the Guilherme Álvaro Hospital in the seaside city of Santos, Brazil. We correlated the most important variables reported in the literature to provide a global comparison of the population affected by the virus in the Santos lowlands.

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Figures

Figure 1
Figure 1. Length of stay (days) of male patients who were discharged or died. The dotted line indicates a downward trend in discharges, while the dashed line indicates a downward trend in deaths with increasing age. Data are reported as means±SD.
Figure 2
Figure 2. Length of stay of female patients who were discharged or died. The dotted line indicates a downward trend in discharges, while the dashed line indicates an upward trend in deaths with increasing age. Data are reported as means±SD.
Figure 3
Figure 3. Relationship between the number of discharges and deaths separated by age group.
Figure 4
Figure 4. Number of deaths from COVID-19 by sex and age group.
Figure 5
Figure 5. Blood tests and biomarkers of discharged COVID-19 patients compared to the COVID-19 patients who died. A, International normalized ratio (INR); B, D-dimer; C, C-reactive protein; and D, Platelet counts. Data are reported as means±SD. ****P<0.001 (t-test).
Figure 6
Figure 6. Immune-mediated mechanism and alterations in C-reactive protein (CRP), D-dimer, international normalized ratio (INR), and platelet levels in COVID-19 patients. ARDS: acute respiratory distress syndrome; IL: interleukin.
See this image and copyright information in PMC

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