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. 2024 Nov 5;36(11):2357-2358.
doi: 10.1016/j.cmet.2024.10.010.

A sympathetic paradigm shift for the role of NPY in obesity

Olivier Lavoie  1 , Alexandre Caron  2
Affiliations
Free article

A sympathetic paradigm shift for the role of NPY in obesity

Olivier Lavoie et al. Cell Metab. .
Free article

Abstract

Neuropeptide Y (NPY) is a powerful orexigenic factor in the brain. However, mice lacking NPY or NPY receptor Y1 (NPY1R) have minimal changes in basal food intake. In a study published in Nature, Zhu et al.1 demystify this paradox and show that central and peripheral NPY have antipodal roles in energy homeostasis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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