Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review

Hye Kyu Min^{1

2}, Sooji Lee^{3

4}, Soeun Kim^{4

5}, Yejun Son^{4

5}, Jaeyu Park^{4

6}, Hyeon Jin Kim^{4

6}, Jinseok Lee⁷, Hayeon Lee^{4

7}, Lee Smith⁸, Masoud Rahmati^{9

10

11}, Jiseung Kang^{12

13}, Nikolaos G Papadopoulos^{14

15}, Seong H Cho^{3

4

16}, Jong Woo Hahn^{17

18}, Dong Keon Yon^{2

3

4

15

19}

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
² Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
³ Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
⁴ Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
⁵ Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
⁶ Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
⁷ Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
⁸ Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
⁹ CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
¹⁰ Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
¹¹ Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.
¹² Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
¹³ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁴ Department of Allergy, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
¹⁵ Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK.
¹⁶ Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
¹⁷ Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
¹⁸ Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea.
¹⁹ Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

PMID: 39506931
DOI: 10.1111/cea.14592

Meta-Analysis

Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review

Hye Kyu Min et al. Clin Exp Allergy. 2025 Jan.

. 2025 Jan;55(1):52-66.

doi: 10.1111/cea.14592. Epub 2024 Nov 7.

Authors

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
² Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
³ Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
⁴ Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
⁵ Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
⁶ Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
⁷ Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
⁸ Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
⁹ CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.
¹⁰ Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.
¹¹ Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.
¹² Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
¹³ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁴ Department of Allergy, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
¹⁵ Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK.
¹⁶ Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
¹⁷ Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
¹⁸ Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea.
¹⁹ Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

PMID: 39506931
DOI: 10.1111/cea.14592

Abstract

Objective: Data on the global prevalence of chronic rhinosinusitis (CRS) is significantly varied and limited across countries and over time. Therefore, we aimed to conduct a comprehensive investigation into the global, regional, and national burden of CRS from the years 1980 to 2021, as well as identify those factors that influence levels of such burden.

Design: We conducted a systematic review and meta-analysis of general population-based observational studies focusing on CRS. We calculated pooled estimates of CRS prevalence and incidence with 95% confidence intervals (CIs). Subgroup analyses were conducted stratifying by sex, age cohorts, geographic regions, smoking status, obesity, and comorbid conditions.

Data sources: PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, and Cochrane databases.

Eligibility criteria for selection: We included general population-based observational studies on CRS published from database inception through October 20, 2023.

Results: A total of 28 eligible studies, encompassing more than 237 million participants and 11,342,923 patients with CRS from 20 countries across four continents, were included in the analysis. Global pooled prevalence of CRS and CRS with nasal polyps (CRSwNP) was found to be 8.71% (95% CI, 6.69-11.33; number of studies, 20) and 0.65% (95% CI, 0.56-0.75; number of studies, 4), respectively. The prevalence of CRS was greater in Europe compared with North America, South America, and Asia; adults compared with children; smokers compared with never-smoker; those with obesity compared with normal weight; and those with comorbidities such as asthma, diabetes mellitus, eczema, and nasal septal deviation. Pooled prevalence of CRS increased from 1980 to 2020 (1980-2000: 4.72%; 95% CI, 2.12-10.49; 2014-2020: 19.40%; 95% CI, 12.12-31.07). Similar patterns were observed in CRS incidence.

Conclusions: Our study provides valuable insights into CRS prevalence and incidence across diverse demographic and clinical factors, highlighting its increasing global burden. The reported prevalence of CRS varies internationally, and may be increasing over time. To enhance data quality and comparability, standardization of reporting methodologies is imperative.

Systematic review registration: PROSPERO (registration no. CRD42024527805).

Keywords: chronic rhinosinusitis; global trend; incidence; meta‐analysis; prevalence; systematic review.

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References

1. R. P. Schleimer, “Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis,” Annual Review of Pathology 12 (2017): 331–357.
1. H. Lee, J. Park, M. Lee, et al., “National Trends in Allergic Rhinitis and Chronic Rhinosinusitis and COVID‐19 Pandemic‐Related Factors in South Korea, From 1998 to 2021,” International Archives of Allergy and Immunology 185 (2024): 1–7.
1. S. W. Lee, S. Y. Kim, S. Y. Moon, et al., “Estimating COVID‐19 Infection and Severity Risks in Patients With Chronic Rhinosinusitis: A Korean Nationwide Cohort Study,” Journal of Allergy and Clinical Immunology: In Practice 9, no. 6 (2021): 2262–2271.
1. A. Ek, R. J. Middelveld, H. Bertilsson, et al., “Chronic Rhinosinusitis in Asthma Is a Negative Predictor of Quality of Life: Results From the Swedish GA(2)LEN Survey,” Allergy 68, no. 10 (2013): 1314–1321.
1. B. K. Tan, R. C. Kern, R. P. Schleimer, and B. S. Schwartz, “Chronic Rhinosinusitis: The Unrecognized Epidemic,” American Journal of Respiratory and Critical Care Medicine 188, no. 11 (2013): 1275–1277.

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Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review

Affiliations

Global Incidence and Prevalence of Chronic Rhinosinusitis: A Systematic Review

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources