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. 1979:(8):38-42.

Development of a closed-loop artificial pancreas

E W Kraegen, R Whiteside, D Bell, Y O Chia, L Lazarus
  • PMID: 395087

Development of a closed-loop artificial pancreas

E W Kraegen et al. Horm Metab Res Suppl. 1979.

Abstract

A closed-loop glucose controlled insulin infusion system was developed, consisting of elements for continuous blood glucose analysis, a computer control system, and infusion systems. Improvements include decreased size, cost reduction and better performance. The algorithm used was a piecewise linear representation of the sigmoidal curve commonly employed. The apparatus has been applied to simulation of the healthy beta cell and glucose clamp studies.

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