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Review
. 2025 Feb;39(1):55-65.
doi: 10.1016/j.hoc.2024.08.002.

Surgical Management of Sarcoma Metastatic to Liver

Brett L Ecker  1 , Robert G Maki  2 , Michael J Cavnar  3 , Ronald P DeMatteo  4
Affiliations
Review

Surgical Management of Sarcoma Metastatic to Liver

Brett L Ecker et al. Hematol Oncol Clin North Am. 2025 Feb.

Abstract

Sarcomas are rare mesenchymal tumors with a propensity for hematogenous metastasis. Gastrointestinal stromal tumor (GIST) is the most common histologic subtype and the most common source of hepatic metastases. In the case of metastatic GIST, neoadjuvant imatinib can be used as a selection tool for the judicious application of surgery, where treatment-responsive patients who undergo resection to prevent the development of treatment-resistant clones have associated 10-year actuarial survival of 40%. Further advances for many of the non-GIST sarcoma subtypes will depend on the development of improved systemic therapies and evaluation of their activity in subtype or molecularly defined trials.

Keywords: GIST; Gastrointestinal stromal tumor; Hepatic tumor; Imatinib; Metastasis; Sarcoma.

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Conflict of interest statement

Disclosure Drs B.L. Ecker, M.J. Cavnar, and R.P. DeMatteo do not have any relevant conflicts of interest to disclose. Dr R.G. Maki reports research support to the institution from SARC: Sarcoma Alliance for Research through Collaboration.

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