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Review
. 2025 Jan;35(1):195-212.
doi: 10.1016/j.giec.2024.05.001. Epub 2024 Jun 15.

Advanced Endoscopic Imaging to Predict Clinical Outcomes in Inflammatory Bowel Disease

Udayakumar Navaneethan  1 , Dennisdhilak Lourdusamy  2
Affiliations
Review

Advanced Endoscopic Imaging to Predict Clinical Outcomes in Inflammatory Bowel Disease

Udayakumar Navaneethan et al. Gastrointest Endosc Clin N Am. 2025 Jan.

Abstract

Advanced endoscopic imaging including high-definition endoscopy, confocal laser endomicroscopy (CLE) and endocytoscopy (EC) serve as an adjunct to predict clinical outcomes in inflammatory bowel disease (IBD). CLE can identify gut barrier dysfunction which correlates with disease behavior and long-term disease outcome. EC allows the assessment of histologic activity. Future controlled studies are warranted to define a definite role of these novel technologies in the management of patients with IBD.

Keywords: Confocal laser endomicroscopy; Crohn’s disease; Endocytoscopy; Endoscopic imaging; Inflammatory bowel disease; Ulcerative colitis.

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Conflict of interest statement

Disclosures U. Navaneethan is a consultant for AbbVie, Janssen and Lilly. U. Navaneethan is on the speaker bureau for Takeda, AbbVie, Pfizer, BMS, Lilly and Janssen. Grant support: None.

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