RH5 antigenic landscape shapes vaccine and antibody development

doi:10.1016/j.tips.2024.10.008

. 2024 Dec;45(12):1092-1094.

doi: 10.1016/j.tips.2024.10.008. Epub 2024 Nov 6.

RH5 antigenic landscape shapes vaccine and antibody development

Palak N Patel¹, Niraj H Tolia²

Affiliations

¹ Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
² Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: niraj.tolia@nih.gov.

PMID: 39510863
PMCID: PMC11624982 (available on 2025-12-01)
DOI: 10.1016/j.tips.2024.10.008

RH5 antigenic landscape shapes vaccine and antibody development

Palak N Patel et al. Trends Pharmacol Sci. 2024 Dec.

. 2024 Dec;45(12):1092-1094.

doi: 10.1016/j.tips.2024.10.008. Epub 2024 Nov 6.

Authors

Palak N Patel¹, Niraj H Tolia²

Affiliations

¹ Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
² Host-Pathogen Interactions and Structural Vaccinology Section, Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: niraj.tolia@nih.gov.

PMID: 39510863
PMCID: PMC11624982 (available on 2025-12-01)
DOI: 10.1016/j.tips.2024.10.008

Abstract

The essential interaction between Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) and basigin makes RH5 a prime target for broadly neutralizing antibodies. A recent study by Barrett et al. mapped the RH5 antigenic landscape from RH5.1/AS01_B vaccinees and identified a potent public antibody clonotype, advancing malaria vaccine and prophylactic antibody development.

Keywords: RH5; blood stage; mAb; malaria; public clonotype; vaccine.

Published by Elsevier Ltd.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

References

1. Barrett JR et al. (2024) Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype. Cell 187, 4964–4980.e4921. 10.1016/j.cell.2024.06.015 - DOI - PMC - PubMed
1. Minassian AM et al. (2021) Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination. Med 2, 701–719.e719. 10.1016/j.medj.2021.03.014 - DOI - PMC - PubMed
1. Crosnier C. et al. (2011) Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534–537. 10.1038/nature10606 - DOI - PMC - PubMed
1. Wong W. et al. (2019) Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex. Nature 565, 118–121. 10.1038/s41586-018-0779-6 - DOI - PubMed
1. Scally SW et al. (2022) PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. Nature Microbiology 7, 2039–2053.10.1038/s41564-022-01261-2 - DOI - PMC - PubMed

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[1] Barrett JR et al. (2024) Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype. Cell 187, 4964–4980.e4921. 10.1016/j.cell.2024.06.015 - DOI - PMC - PubMed

[2] Barrett JR et al. (2024) Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype. Cell 187, 4964–4980.e4921. 10.1016/j.cell.2024.06.015 - DOI - PMC - PubMed

[3] Minassian AM et al. (2021) Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination. Med 2, 701–719.e719. 10.1016/j.medj.2021.03.014 - DOI - PMC - PubMed

[4] Minassian AM et al. (2021) Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination. Med 2, 701–719.e719. 10.1016/j.medj.2021.03.014 - DOI - PMC - PubMed

[5] Crosnier C. et al. (2011) Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534–537. 10.1038/nature10606 - DOI - PMC - PubMed

[6] Crosnier C. et al. (2011) Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534–537. 10.1038/nature10606 - DOI - PMC - PubMed

[7] Wong W. et al. (2019) Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex. Nature 565, 118–121. 10.1038/s41586-018-0779-6 - DOI - PubMed

[8] Wong W. et al. (2019) Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex. Nature 565, 118–121. 10.1038/s41586-018-0779-6 - DOI - PubMed

[9] Scally SW et al. (2022) PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. Nature Microbiology 7, 2039–2053.10.1038/s41564-022-01261-2 - DOI - PMC - PubMed

[10] Scally SW et al. (2022) PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. Nature Microbiology 7, 2039–2053.10.1038/s41564-022-01261-2 - DOI - PMC - PubMed

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RH5 antigenic landscape shapes vaccine and antibody development

Affiliations

RH5 antigenic landscape shapes vaccine and antibody development

Authors

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Conflict of interest statement

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