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Review
. 2024 Oct 24:15:1482316.
doi: 10.3389/fphar.2024.1482316. eCollection 2024.

Recent advances in the structures and bioactivities of benzopyrans derived from marine fungi: a review

Yidan Xi #  1   2 , Huannan Wang #  2 , Lixiang Sun  2 , Xueyang Ma  2 , Shuncun Zhang  2 , Zhen Zhang  2
Affiliations
Review

Recent advances in the structures and bioactivities of benzopyrans derived from marine fungi: a review

Yidan Xi et al. Front Pharmacol. .

Abstract

Marine fungi represent a treasure trove of bioactive secondary metabolites, with benzopyran compounds emerging as a significant class of these natural products. This review delves into the structural diversity, biological activities, and sources of benzopyran compounds, highlighting their isolation from marine fungi inhabiting diverse environments such as sponges, marine sediments, algae, mangroves, and corals. Our literature search, conducted from 2000 to 2023, has identified a wealth of benzopyran compounds, showcasing their potential as lead compounds in drug development. The characteristics of benzopyran from marine fungi are explored, encompassing various subclasses such as chromones, isocoumarins, citrinins, and other related compounds. These compounds exhibit a remarkable chemical diversity, which is crucial for their diverse biological activities. The potential of benzopyran compounds in drug development is also discussed, emphasizing their roles in anti-tumor, antibacterial, anti-inflammatory, and enzyme inhibitory activities. In recent years, a remarkable 210 bioactive benzopyran compounds have been isolated from the secondary metabolites of marine fungi. These findings underscore the importance of marine fungi as a source of novel bioactive compounds, offering a plethora of potential lead compounds for the development of marine-derived drugs. This review aims to provide a comprehensive overview of the current state of research on benzopyran compounds, setting the stage for future advancements in the field of marine natural products.

Keywords: benzopyrans; biological activity; isolation and identification; marine fungi; secondary metabolites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The annual isolation of novel and bioactive benzopyran compounds from marine fungi.
FIGURE 2
FIGURE 2
Principal origins of marine fungi yielding benzopyrans.
FIGURE 3
FIGURE 3
The distribution of marine fungi analyzed in this study.
FIGURE 4
FIGURE 4
The bioactivity of Benzopyrans reviewed in this paper.
FIGURE 5
FIGURE 5
Structural formulas of the isolated compounds 1–50.
FIGURE 6
FIGURE 6
Structural formulas of the isolated compounds 51–97.
FIGURE 7
FIGURE 7
Structural formulas of the isolated compounds 98–161.
FIGURE 8
FIGURE 8
Structural formulas of the isolated compounds 162–193.
FIGURE 9
FIGURE 9
Structural formulas of the isolated compounds 194–204.
FIGURE 10
FIGURE 10
Structural formulas of the isolated compounds 205–210.
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