Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug;160(2):246-253.
doi: 10.25259/IJMR_218_2024.

Assessment of health-related quality of life in individuals with interstitial lung diseases in a tertiary care hospital in south India

Kimberley D'Souza  1 , Tharini Ravichandran  2 , Kavitha Venkatnarayan  2 , Chitra Veluthat  2 , Uma Devaraj  2 , Priya Ramachandran  2 , Uma Maheswari Krishnaswamy  2
Affiliations

Assessment of health-related quality of life in individuals with interstitial lung diseases in a tertiary care hospital in south India

Kimberley D'Souza et al. Indian J Med Res. 2024 Aug.

Abstract

Background & objectives Interstitial lung diseases (ILD) cause progressive symptoms and decline in lung functions which impact health-related quality of life (HRQoL). Although HRQoL is gaining wider acceptance as an endpoint for disease perception, limited data is available regarding the same in Indians with ILD. Hence, this study was undertaken to assess HRQoL and its correlation with lung function parameters in individuals with ILD in a tertiary care setting in south India. Methods A hundred and fifty-nine consecutive patients with ILD were recruited between June 2022 to December 2023. HRQoL was assessed using the ILD specific K-BILD, generic EQ-5D-5L and an adapted version of the validated PESaM questionnaires. Correlation between various domains of the three questionnaires and lung function parameters was analyzed followed by linear regression analysis. Results The study population consisted predominantly of females (64.1%), with CTD-ILD being the most common ILD (40.8%). HRQoL impairment was noted, predominantly affecting the 'breathlessness and activity' domain and significant correlation was noted between K-BILD and EQ-5D-5L across domains. On regression analysis, FVC, 6-minute walk distance and desaturation were independent predictors of HRQoL. Type of ILD and disease duration did not have a significant association with HRQoL measures. Interpretation & conclusions 'Breathlessness and activity' domain of HRQoL was affected the most in participants with ILD. Forced vital capacity, six-minute walk distance and exercise induced desaturation were independent predictors of HRQoL among individuals with ILD.

Keywords: HRQoL; interstitial lung diseases; patient reported outcomes; questionnaire.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure.
Figure.
Results of health-related quality of life questionnaires. EQ VAS, EuroQol Visual Analog Scale; K-BILD, King’s Brief Interstitial Lung Disease - B&A, breathlessness and activity domain, Chest, chest symptoms domain, Psych, Psychological domain.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Maher TM. Interstitial Lung Disease: A Review. JAMA. 2024 May 21;331:1655–1665. - PubMed
    1. Swigris JJ, Brown KK, Abdulqawi R, Buch K, Dilling DF, Koschel D, et al. Patients’ perceptions and patient-reported outcomes in progressive-fibrosing interstitial lung diseases. Eur Respir Rev. 2018;27:180075. - PMC - PubMed
    1. Swigris JJ, Fairclough D. Patient-reported outcomes in idiopathic pulmonary fibrosis research. Chest. 2012;142:291–97. - PMC - PubMed
    1. Aronson KI, Suzuki A. Health related quality of life in interstitial lung disease: Can We Use the same concepts around the world? Front Med (Lausanne) 2021;8:745908. - PMC - PubMed
    1. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26:319–38. - PubMed