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. 2024 Nov 4;7(11):e2444238.
doi: 10.1001/jamanetworkopen.2024.44238.

Parental Acceptance of Fetal Tissue Donation

Yousif Dawood  1   2   3 , Maurice J B van den Hoff  2   3 , Anita C J Ravelli  2   3   4 , Bernadette S de Bakker  2   3   5 , Eva Pajkrt  2   3
Affiliations

Parental Acceptance of Fetal Tissue Donation

Yousif Dawood et al. JAMA Netw Open. .

Abstract

Importance: Human fetal tissue is essential for biomedical research, providing unparalleled insights into human development and disease.

Objective: To assess changes in parental decisions to donate fetal tissue following termination of pregnancy after the introduction of the Dutch Fetal Biobank (DFB) and to identify factors associated with consent to donate.

Design, setting, and participants: This cohort study collected data from all individuals assigned female at birth (hereafter referred to as participants) who underwent a termination of pregnancy at the Amsterdam University Medical Center from January 1, 2008, to December 31, 2022. No exclusion criteria were applied.

Exposure: Introduction of the DFB on September 1, 2017, which offers the option to donate fetal tissue after pregnancy termination.

Main outcome and measure: Rates of fetal tissue donation before and after DFB introduction and associations between patient characteristics (maternal age, race and ethnicity, socioeconomic status, gestational age, and reason for termination) and consent to donation were assessed using multivariable binary logistic regression modeling.

Results: Of a total of 1272 participants (mean [SD] age, 33.0 [5.4] years), 576 (45.3%) were nulliparous. The mean (SD) gestational age at termination was 18 weeks 3 days (26 days), and reasons for termination were primarily because of structural defects (567 participants [44.6%]), with only a small portion (58 participants [4.6%]) terminating for social reasons (eg, unwanted or unplanned pregnancy). Fetal tissue donations increased from 1.2% (8 donations among 663 terminations) before the DFB introduction to 21.7% (132 donations among 609 terminations) after its introduction. This rise was primarily due to a shift from collective cremation to donation, while individual cremation or burial rates remained stable. The consent rate was 30.3% (132 of 436) for participants informed about the donation option. No significant demographic differences were found between participants who consented and those who did not, except for gestational age; consent rates decreased with advanced gestational age (odds ratio per week, 0.88; 95% CI, 0.83-0.94). Higher consent rates were observed for terminations due to social reasons (odds ratio, 3.56; 95% CI, 1.40-9.10).

Conclusions and relevance: These findings suggest that a substantial proportion of individuals may be willing to donate fetal tissue for biomedical research after pregnancy termination. Integrating donation options in posttermination counseling respects patient autonomy and could ethically increase tissue availability for research. Expanding biobanks and fostering international collaboration is crucial for standardizing practices and ensuring equitable research benefits.

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Conflict of interest statement

Conflict of Interest Disclosures: Prof Pajkrt reported receiving funding for projects from Stichting Stoptevroegbevallen, grants from ZonMW and Amsterdam Reproduction & Development, and personal fees from Amsterdam Reproduction & Development outside the submitted work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Parental Choice for Fetal Remains After Pregnancy Termination
aIndicates the start of the Dutch Fetal Biobank on September 1, 2017.
Figure 2.
Figure 2.. Study Flowchart
aAutopsy was performed after termination of pregnancy; therefore, inclusion in the Dutch Fetal Biobank (DFB) was not possible.
See this image and copyright information in PMC

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References

    1. Brumbaugh J, Aguado BA, Lysaght T, Goldstein LSB. Human fetal tissue is critical for biomedical research. Stem Cell Reports. 2023;18(12):2300-2312. doi:10.1016/j.stemcr.2023.10.008 - DOI - PMC - PubMed
    1. Boonstra H. Fetal tissue research: a weapon and a casualty in the war against abortion. Guttmacher Policy Rev. 2016;19:9-15.
    1. Wadman M. The truth about fetal tissue research. Nature. 2015;528(7581):178-181. doi:10.1038/528178a - DOI - PubMed
    1. Dawood Y, Buijtendijk MFJ, Bohly D, et al. . Human embryonic and fetal biobanking: establishing the Dutch Fetal Biobank and a framework for standardization. Dev Cell. 2023;58(24):2826-2835. doi:10.1016/j.devcel.2023.11.019 - DOI - PubMed
    1. Buijtendijk MFJ, Peters JJ, Visser SC, et al. . Morphological variations of the human spleen: no evidence for a multifocal or lobulated developmental origin. Br J Radiol. 2023;96(1145):20220744. doi:10.1259/bjr.20220744 - DOI - PMC - PubMed

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