Extensive LDL-cholesterol lowering by PCSK9 inhibitor on the risk of venous thrombosis
- PMID: 39514369
- PMCID: PMC11724136
- DOI: 10.1093/ehjcvp/pvae077
Extensive LDL-cholesterol lowering by PCSK9 inhibitor on the risk of venous thrombosis
Figures
Comment on
-
Role of PCSK9 inhibitors in venous thromboembolism: current evidence and unmet clinical needs.Eur Heart J Cardiovasc Pharmacother. 2025 Jan 11;10(8):719-724. doi: 10.1093/ehjcvp/pvae076. Eur Heart J Cardiovasc Pharmacother. 2025. PMID: 39406397 Free PMC article. Review.
Similar articles
-
A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.J Lipid Res. 2022 Nov;63(11):100293. doi: 10.1016/j.jlr.2022.100293. Epub 2022 Oct 6. J Lipid Res. 2022. PMID: 36209894 Free PMC article.
-
Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥ 70 mg/dl despite maximal tolerated cholesterol lowering therapy.Lipids Health Dis. 2016 Mar 12;15:55. doi: 10.1186/s12944-016-0227-2. Lipids Health Dis. 2016. PMID: 26968977 Free PMC article.
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9) Deficiency is Protective Against Venous Thrombosis in Mice.Sci Rep. 2017 Oct 30;7(1):14360. doi: 10.1038/s41598-017-14307-x. Sci Rep. 2017. PMID: 29084995 Free PMC article.
-
MK-0616: an oral PCSK9 inhibitor for hypercholesterolemia treatment.Expert Opin Investig Drugs. 2023 Jul-Dec;32(10):873-878. doi: 10.1080/13543784.2023.2267972. Epub 2023 Nov 6. Expert Opin Investig Drugs. 2023. PMID: 37815341 Review.
-
Targeting PCSK9 to tackle cardiovascular disease.Pharmacol Ther. 2023 Sep;249:108480. doi: 10.1016/j.pharmthera.2023.108480. Epub 2023 Jun 17. Pharmacol Ther. 2023. PMID: 37331523 Review.
References
-
- Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, Sever PS, Pedersen TR. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med 2017;376:1713–1722. - PubMed
-
- Libby P, Schoenbeck U, Mach F, Selwyn AP, Ganz P. Current concepts in cardiovascular pathology: the role of LDL cholesterol in plaque rupture and stabilization. Am J Med 1998;104:14S–18S. - PubMed
-
- Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med 1992;326:310–318. - PubMed
-
- van der Stoep M, Korporaal SJ, Van Eck M. High-density lipoprotein as a modulator of platelet and coagulation responses. Cardiovasc Res 2014;103:362–371. - PubMed
-
- Zuin MCA, Valle CD, Rosa CD, Maloberti A, Mojoli M, Rizzo M, Ciccirillo F, Madrid A, Riccio C, Grimaldi M, Colivicchi F, Oliva F, Temporelli PL. Role of PCSK9 inhibitor in venous thromoembolism: current evidece and unmet needs. Eur Heart J-Cardiovasc Pharmacother 2024;in press. 10.1093/ehjcvp/pvae076 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous