Follow the CSF flow: probing multiciliated ependymal cells in brain pathology

Abstract

Multiciliated ependymal cells regulate cerebrospinal fluid (CSF) microcirculation and form a dynamic CSF-brain interface. Emerging evidence suggests that ependymal cells enter reactive states in response to pathology that are associated with ciliary and junctional protein alterations. The drivers of these alterations, likely from both acquired and inherited mechanisms, remain elusive.

Keywords: brain border; brain ventricles; cerebrospinal fluid; ependymoglial cells; reactive glia; ventriculomegaly.