Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr 19;2(1):33.
doi: 10.1038/s44276-024-00051-z.

Viruses in glioblastoma: an update on evidence and clinical trials

Bavani Gunasegaran  1 , Caroline L Ashley  2   3 , Felix Marsh-Wakefield  2   3   4 , Gilles J Guillemin  5 , Benjamin Heng  6
Affiliations
Review

Viruses in glioblastoma: an update on evidence and clinical trials

Bavani Gunasegaran et al. BJC Rep. .

Abstract

Background: Glioblastoma (GB) is a lethal and aggressive brain tumour. While molecular characteristics of GB is studied extensively, the aetiology of GB remains uncertain. The interest in exploring viruses as a potential contributor to the development of GB stems from the notion that viruses are known to play a key role in pathogenesis of other human cancers such as cervical cancer. Nevertheless, the role of viruses in GB remains controversial.

Methods: This review delves into the current body of knowledge surrounding the presence of viruses in GB as well as provide updates on clinical trials examining the potential inclusion of antiviral therapies as part of the standard of care protocol.

Conclusions: The review summarises current evidences and important gaps in our knowledge related to the presence of viruses in GB.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010. Neuro Oncol. 2013;15:ii1–56. - PMC - PubMed
    1. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23:1231–51. - PMC - PubMed
    1. Louis DN, Wesseling P, Aldape K, Brat DJ, Capper D, Cree IA, et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol. 2020;30:844–56. - PMC - PubMed
    1. Brat DJ, Aldape K, Colman H, Holland EC, Louis DN, Jenkins RB, et al. cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV. Acta Neuropathol. 2018;136:805–10. - PMC - PubMed
    1. Gallego Perez-Larraya J, Hildebrand J. Brain metastases. Handb Clin Neurol. 2014;121:1143–57. - PubMed

LinkOut - more resources