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. 2024 Oct 30;16(21):3658.
doi: 10.3390/cancers16213658.

Analysis of Swallowing Functional Preservation by Surgical Versus CRT After Induction Chemotherapy for Oropharyngeal Cancer

Yung-An Tsou  1   2   3 , Wen-Dien Chang  4 , Nai-Hsin Meng  2   3   5 , Chun-Hung Hua  1   2
Affiliations

Analysis of Swallowing Functional Preservation by Surgical Versus CRT After Induction Chemotherapy for Oropharyngeal Cancer

Yung-An Tsou et al. Cancers (Basel). .

Abstract

Objectives: This retrospective observational study investigated to determine whether surgery or chemoradiation therapy after induction chemotherapy leads to better swallow function for oropharyngeal cancer patients. Methods: We documented the treatment paths and results of 267 patients with oropharyngeal squamous cell cancer (OPSCC). By quantifying nasogastric (NG) tube usage, surgery after induction chemotherapy (IC-surgery), and chemoradiation therapy after induction chemotherapy (IC-CRT) could be compared to determine the effectiveness of each. Cancer stages were also recorded concerning treatment options. The differences in NG tube usage IC-surgery and IC-CRT groups were compared. The NG tube dependence rates were also presented. Results: The prognosis and tube dependence differed significantly between the two groups. The IC-surgery had a better prognosis compared to IC-CRT for oropharyngeal cancer. The findings indicated that NG tube dependence was greater in advanced tumor stage 4 compared to stages 1-3, and NG tube dependence rates were higher for patients who underwent chemoradiation therapy after induction chemotherapy. Swallowing function was better in the IC-surgery group compared to the IC-CRT group. Conclusions: Higher NG tube retention rates and NG dependence are found in OPSCC patients who choose CRT as their treatment and also in the advanced-stage group.

Keywords: chemoradiation; dysphagia; nasogastric tube; oropharyngeal squamous cell cancer; surgery.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
NG rate for stages 1–3 versus stage 4.
Figure 2
Figure 2
NG rate for IC–surgery vs. IC-CRT.
Figure 3
Figure 3
NG rate for IC–surgery vs. IC-CRT at 3 (A), 6 (B), 9 (C), and 12 (D) months.
See this image and copyright information in PMC

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